6kbr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex== | |
| - | + | <StructureSection load='6kbr' size='340' side='right'caption='[[6kbr]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6kbr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KBR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kbr OCA], [http://pdbe.org/6kbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kbr RCSB], [http://www.ebi.ac.uk/pdbsum/6kbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kbr ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kawaguchi, Y]] | [[Category: Kawaguchi, Y]] | ||
[[Category: Nishimiya, D]] | [[Category: Nishimiya, D]] | ||
| + | [[Category: Cystine knot protein]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Protease inhibitor]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Protein engineering]] | ||
| + | [[Category: Structural analysis]] | ||
Revision as of 10:43, 17 July 2019
Crystal structure of Human KLK4 and SPINK2 derived KLK4 inhibitor complex
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