6qkp

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m (Protected "6qkp" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6qkp is ON HOLD
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==NMR solution structure of LSR2 binding domain.==
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<StructureSection load='6qkp' size='340' side='right'caption='[[6qkp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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Authors: Barthe, P., Cohen-Gonsaud, M., Mukamolova, G.V.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qkp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QKP FirstGlance]. <br>
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Description: NMR solution structure of LSR2 binding domain.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qkp OCA], [http://pdbe.org/6qkp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qkp RCSB], [http://www.ebi.ac.uk/pdbsum/6qkp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qkp ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LSR2_MYCTU LSR2_MYCTU]] DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes, including major virulence factors or antibiotic-induced genes, such as iniBAC or efpA. May coordinate global gene regulation and virulence. Also protects mycobacteria against reactive oxygen intermediates during macrophage infection by acting as a physical barrier to DNA degradation.<ref>PMID:17590082</ref> <ref>PMID:18187505</ref> <ref>PMID:19237572</ref> <ref>PMID:20133735</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Barthe, P]]
[[Category: Cohen-Gonsaud, M]]
[[Category: Cohen-Gonsaud, M]]
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[[Category: Mukamolova, G.V]]
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[[Category: Mukamolova, G V]]
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[[Category: Barthe, P]]
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[[Category: Dna binding protein]]
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[[Category: Dna organisation]]
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[[Category: Pknb substrate]]
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[[Category: Transcriptional regulator]]
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[[Category: Tuberculosis]]

Revision as of 10:50, 17 July 2019

NMR solution structure of LSR2 binding domain.

PDB ID 6qkp

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