1tgh

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[[Image:1tgh.gif|left|200px]]
[[Image:1tgh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tgh |SIZE=350|CAPTION= <scene name='initialview01'>1tgh</scene>, resolution 2.900&Aring;
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The line below this paragraph, containing "STRUCTURE_1tgh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= TBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1tgh| PDB=1tgh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgh OCA], [http://www.ebi.ac.uk/pdbsum/1tgh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tgh RCSB]</span>
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}}
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'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX'''
'''TATA BINDING PROTEIN (TBP)/DNA COMPLEX'''
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[[Category: Dickerson, R E.]]
[[Category: Dickerson, R E.]]
[[Category: Juo, Z S.]]
[[Category: Juo, Z S.]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: dna binding protein]]
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[[Category: Dna binding protein]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:39:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:55:43 2008''
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Revision as of 06:39, 24 April 2008

Image:1tgh.gif

Template:STRUCTURE 1tgh

TATA BINDING PROTEIN (TBP)/DNA COMPLEX


Contents

Overview

The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.

Disease

Known disease associated with this structure: Huntington disease-like-4 OMIM:[600075], Parkinson disease OMIM:[600075], Spinocerebellar ataxia 17 OMIM:[600075]

About this Structure

1TGH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1TGH with [TATA-Binding Protein]. Full crystallographic information is available from OCA.

Reference

How proteins recognize the TATA box., Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE, J Mol Biol. 1996 Aug 16;261(2):239-54. PMID:8757291 Page seeded by OCA on Thu Apr 24 09:39:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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