1uzb
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1uzb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uzb, resolution 1.40Å" /> '''1-PYRROLINE-5-CARBO...)
Next diff →
Revision as of 15:37, 29 October 2007
|
1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE
Overview
Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDh) plays an important, role in the metabolic pathway from proline to glutamate. It irreversibly, catalyzes the oxidation of glutamate-gamma-semialdehyde, the product of, the non-enzymatic hydrolysis of Delta(1)-pyrroline-5-carboxylate, into, glutamate with the reduction of NAD(+) into NADH. We have confirmed the, P5CDh activity of the Thermus thermophilus protein TT0033 (TtP5CDh), and, determined the crystal structure of the enzyme in the ligand-free form at, 1.4 A resolution. To investigate the structural basis of TtP5CDh function, the TtP5CDh structures with NAD(+), with NADH, and with its product, glutamate were determined at 1.8 A, 1.9 A, and 1.4 A resolution, respectively. The solved structures suggest an overall view of the P5CDh, ... [(full description)]
About this Structure
1UZB is a [Single protein] structure of sequence from [Thermus thermophilus] with MRD as [ligand]. Full crystallographic information is available from [OCA].
Reference
Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase., Inagaki E, Ohshima N, Takahashi H, Kuroishi C, Yokoyama S, Tahirov TH, J Mol Biol. 2006 Sep 22;362(3):490-501. Epub 2006 Jul 29. PMID:16934832
Page seeded by OCA on Mon Oct 29 17:41:46 2007
