Glycated hemoglobin
From Proteopedia
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==Structure== | ==Structure== | ||
<StructureSection load='' size='340' side='right' caption='Glycated hemoglobin (PDB ID 5hy8)' scene='82/821067/Overall/2'> | <StructureSection load='' size='340' side='right' caption='Glycated hemoglobin (PDB ID 5hy8)' scene='82/821067/Overall/2'> | ||
| - | Hemoglobin is the protein that transports oxygen in our blood. In the structure shown in the initial view (<scene name='82/821067/Overall/3'>reload</scene>), all four heme groups<jmol> | + | Hemoglobin is the protein that transports oxygen in our blood. In the structure shown in the initial view (<scene name='82/821067/Overall/3'>reload</scene>), all four heme groups <jmol> |
<jmolLink> | <jmolLink> | ||
<script>select HEM; selectionHalos ON; delay 0.5;selectionHalos OFF; </script> | <script>select HEM; selectionHalos ON; delay 0.5;selectionHalos OFF; </script> | ||
<text>(☼)</text> | <text>(☼)</text> | ||
</jmolLink> | </jmolLink> | ||
| - | </jmol> bind to oxygen. Two amino acid side chains are covalently bound to sugar molecules <jmol> | + | </jmol> bind to oxygen <jmol> |
| + | <jmolLink> | ||
| + | <script>select OXY; selectionHalos ON; delay 0.5;selectionHalos OFF; </script> | ||
| + | <text>(☼)</text> | ||
| + | </jmolLink> | ||
| + | </jmol>Two amino acid side chains are covalently bound to sugar molecules <jmol> | ||
<jmolLink> | <jmolLink> | ||
<script>select FRU; selectionHalos ON; delay 0.5;selectionHalos OFF; </script> | <script>select FRU; selectionHalos ON; delay 0.5;selectionHalos OFF; </script> | ||
Revision as of 14:54, 17 July 2019
Glycated Hemoglobin is a form of hemoglobin with sugars attached to certain amino acid side chains. When blood sugar levels in an individual are high for long periods of time (hyperglycemia) as is the case for people with diabetes) when blood sugar is not managed, these sugar modifications accumulate. The so-called HbA1c test[1] is used as a measure of hyperglycemia over the past ~3 months. The time span of 3 months corresponds roughly to the average time red blood cells remain in the blood stream. When they are replenished by fresh cells, these carry hemoglobin that does not yet have the modification [2].
Structure
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References
- ↑ Yonehara S, Inamura N, Fukuda M, Sugiyama K. Use of fructosyl peptide oxidase for HbA1c assay. J Diabetes Sci Technol. 2015 Mar;9(2):200-5. doi: 10.1177/1932296815569573. Epub , 2015 Jan 28. PMID:25633966 doi:http://dx.doi.org/10.1177/1932296815569573
- ↑ https://pdb101.rcsb.org/global-health/diabetes-mellitus/monitoring/diagnosis?more=y
- ↑ https://en.wikipedia.org/wiki/Amadori_rearrangement
- ↑ https://www.cdc.gov/nchs/data/nhanes/nhanes_07_08/GHB_E_met_Tosoh_22_Plus.pdf
