GTP-binding protein

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== Structural highlights ==
== Structural highlights ==
''E. coli'' small GTPase ERA binds GDP in a cavity formed by <scene name='46/463251/Cv/3'>7 highly conserved regions G1, G4, G5</scene><ref>PMID:19706445</ref>. <scene name='46/463251/Cv/8'>GDP binding site</scene>. Water molecules are shown as red spheres.
''E. coli'' small GTPase ERA binds GDP in a cavity formed by <scene name='46/463251/Cv/3'>7 highly conserved regions G1, G4, G5</scene><ref>PMID:19706445</ref>. <scene name='46/463251/Cv/8'>GDP binding site</scene>. Water molecules are shown as red spheres.
 +
 +
== 3D Structures of GTP-binding protein ==
 +
[[GTP-binding protein 3D structures]]
 +
</StructureSection>
</StructureSection>
__NOTOC__
__NOTOC__
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*'''Small GTP-binding protein'''
*'''Small GTP-binding protein'''
-
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
 
**[[2eki]] – hGBP TGS domain – NMR - human<br />
**[[2eki]] – hGBP TGS domain – NMR - human<br />
 +
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[2qtf]] – SsHflx<br />
**[[2qtf]] – SsHflx<br />
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**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
 +
**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
*GTP-binding protein complex with nucleotide
*GTP-binding protein complex with nucleotide
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**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
 +
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
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**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br />
**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br />
 +
**[[6b9f]], [[6b9e]], [[6b9d]] – hGDP3 cytoplasmic domain (mutant) + GDP<br />
* GTP-binding protein LepA
* GTP-binding protein LepA
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*'''Ras-related small GTP-binding protein'''
*'''Ras-related small GTP-binding protein'''
-
**[[3llu]] – hC nucleotide-binding domain<br />
+
**[[3llu]] – hRag-C nucleotide-binding domain<br />
 +
**[[2rhd]] – Rab-1a – ''Cryptosporidium parvum''<br />
*Ras-related small GTP-binding protein complex with nucleotide
*Ras-related small GTP-binding protein complex with nucleotide
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**[[2erx]] – hDiRas2 + Pi + GDP<br />
**[[2erx]] – hDiRas2 + Pi + GDP<br />
**[[3x1z]], [[3x1y]], [[3x1x]], [[3x1w]] – hRab-1B (mutant) + GPPNHP<br />
**[[3x1z]], [[3x1y]], [[3x1x]], [[3x1w]] – hRab-1B (mutant) + GPPNHP<br />
-
**[[1x3s]] – hRab-18 + GPPNHP<br />
 
**[[1yu9]] - hRab-4A + GPPNHP<br />
**[[1yu9]] - hRab-4A + GPPNHP<br />
 +
**[[1yzq]] - hRab-6 + GNP<br />
 +
**[[1x3s]] – hRab-18 + GPPNHP
 +
**[[6huf]] - hRab-27A + GNP<br />
**[[2atx]] – hTc10 + GPPNHP<br />
**[[2atx]] – hTc10 + GPPNHP<br />
**[[1g16]] – ySec4 + GDP<br />
**[[1g16]] – ySec4 + GDP<br />
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**[[3kuc]] – hRap-1A + proto oncogene Ser/Thr protein kinase<br />
**[[3kuc]] – hRap-1A + proto oncogene Ser/Thr protein kinase<br />
**[[3cf6]] - hRap-1A + Rap guanine nucleotide exchange factor 4<br />
**[[3cf6]] - hRap-1A + Rap guanine nucleotide exchange factor 4<br />
-
**[[4kvg]] – hRab-1A + RIAM<br />
 
**[[3brw]] - hRap-1B + Rap GTPase-activating protein<br />
**[[3brw]] - hRap-1B + Rap GTPase-activating protein<br />
 +
**[[4kvg]] – hRab-1A + RIAM<br />
**[[6ba6]] – hRab-1B + talin-1<br />
**[[6ba6]] – hRab-1B + talin-1<br />
**[[4m8n]] – hRab-1B + plexin<br />
**[[4m8n]] – hRab-1B + plexin<br />
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**[[3tw8]] – hRab-1C + DENND<br />
**[[3tw8]] – hRab-1C + DENND<br />
**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
 +
**[[6ekk]] – hRab-35 + connecdenn + GDP<br />
 +
**[[6if2]] – hRab-35 (mutant) + iporin + GTP<br />
 +
**[[6if3]] – hRab-35 (mutant) + ACAP2 + GTP<br />
 +
**[[6ces]] – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM<br />
 +
**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
*'''Interferon-induced GTP-binding protein'''
*'''Interferon-induced GTP-binding protein'''
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**[[2rex]] – hRho6 + plexin-B1<br />
**[[2rex]] – hRho6 + plexin-B1<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
 +
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
**[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
**[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
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*'''Small GTP-binding protein'''
*'''Small GTP-binding protein'''
-
**[[2rhd]] – Rab-1a – ''Cryptosporidium parvum''<br />
+
**[[5kh0]] – GBP – ''Thermotoga neapolitana''<br />
-
**[[1yzq]] - hRab-6 + GNP<br />
+
-
**[[3qq5]] – GBP – ''Thermotoga neapolitana''<br />
+
*'''Small GTP-binding protein ERA'''
*'''Small GTP-binding protein ERA'''
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*'''Small GTP-binding protein Rheb'''
*'''Small GTP-binding protein Rheb'''
-
**[[1xtq]] – hRheb + GDP<br />
+
**[[1xtq]], [[5yxh]] – hRheb + GDP<br />
**[[1xts]] - hRheb + GTP<br />
**[[1xts]] - hRheb + GTP<br />
**[[1xtr]] - hRheb + GPPNHP<br />
**[[1xtr]] - hRheb + GPPNHP<br />
**[[3sea]] - hRheb + GDP + GNP<br />
**[[3sea]] - hRheb + GDP + GNP<br />
 +
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
 +
**[[3t5g]] – hRheb + GMP-PDE delta<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
**[[4o2r]] - mRheb (mutant) + GDP <br />
**[[4o2r]] - mRheb (mutant) + GDP <br />
**[[3t5g]] – hRheB + GMP-PDE δ<br />
**[[3t5g]] – hRheB + GMP-PDE δ<br />
 +
**[[2l0x]] – rRheb + GDP<br />
*'''Small GTP-binding protein Gem'''
*'''Small GTP-binding protein Gem'''
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**[[4ol0]] – hRan + importin 12 + GTP<br />
**[[4ol0]] – hRan + importin 12 + GTP<br />
**[[3ea5]] – hRan (mutant) + importin β1 subunit + GDP <br />
**[[3ea5]] – hRan (mutant) + importin β1 subunit + GDP <br />
 +
**[[6q82]] – hRan (mutant) + importin β-like protein + GTP<br />
**[[4c0q]] - hRan (mutant) + importin 12 + GTP <br />
**[[4c0q]] - hRan (mutant) + importin 12 + GTP <br />
**[[3nc1]] – hRan (mutant) + exportin 1 + GTP <br />
**[[3nc1]] – hRan (mutant) + exportin 1 + GTP <br />
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**[[5bxq]] – dRan + NTF-2 + GDP <br />
**[[5bxq]] – dRan + NTF-2 + GDP <br />
-
*Ran quaternary complex
+
*Ran larger complex
**[[3gjx]] – hRan + snurportin 1 + exportin 1 + GTP <br />
**[[3gjx]] – hRan + snurportin 1 + exportin 1 + GTP <br />
**[[3nby]], [[3nbz]], [[3nc0]] – hRan (mutant) + snurportin 1 + exportin 1 + GTP <br />
**[[3nby]], [[3nbz]], [[3nc0]] – hRan (mutant) + snurportin 1 + exportin 1 + GTP <br />
-
**[[1k5d]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
+
**[[1k5d]], [[5zpu]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
**[[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[4hb3]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP <br />
**[[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[4hb3]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP <br />
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**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
 +
**[[6cit]] – hRan + Ran-specific GTPase-activating protein + exportin + NS2<br />
 +
**[[6a3e]], [[6a3c]], [[6a3b]], [[6a3a]], [[6a38]] – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP<br />
 +
**[[5ytb]], [[5yst]], [[5yro]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP<br />
 +
**[[5ysu]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP + plumbagin<br />
**[[5uww]], [[5uwu]], [[5uwt]], [[5uws]], [[5uwr]], [[5uwq]], [[5uwp]], [[5uwo]], [[5uwj]], [[5uwi]], [[5uwh]], [[5dif]], [[5di9]], [[5dhf]], [[5dha]], [[5dh9]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + peptide<br />
**[[5uww]], [[5uwu]], [[5uwt]], [[5uws]], [[5uwr]], [[5uwq]], [[5uwp]], [[5uwo]], [[5uwj]], [[5uwi]], [[5uwh]], [[5dif]], [[5di9]], [[5dhf]], [[5dha]], [[5dh9]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + peptide<br />
**[[3zjy]] – hRan (mutant) + importin 13 + EIF-1A + GTP <br />
**[[3zjy]] – hRan (mutant) + importin 13 + EIF-1A + GTP <br />
 +
**[[6q84]] – hRan (mutant) + importin β-like protein + EIF-4D + GTP<br />
**[[5dlq]] – hRan (mutant) + exportin 4 + EIF-5A + GTP <br />
**[[5dlq]] – hRan (mutant) + exportin 4 + EIF-5A + GTP <br />
**[[5dis]] – hRan (mutant) + exportin 1 + RNA U transporter + Nup214 + GTP <br />
**[[5dis]] – hRan (mutant) + exportin 1 + RNA U transporter + Nup214 + GTP <br />

Revision as of 10:01, 18 July 2019

E. coli small GTP-binding protein ERA complex with GDP and sulfate (PDB code 3ieu)

Drag the structure with the mouse to rotate

3D Structures of GTP-binding protein

Updated on 18-July-2019


See Also

References

  1. ↑ Preininger AM, Hamm HE. G protein signaling: insights from new structures. Sci STKE. 2004 Jan 27;2004(218):re3. PMID:14762218 doi:http://dx.doi.org/10.1126/stke.2182004re3
  2. ↑ Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153-208. PMID:11152757
  3. ↑ Lania A, Mantovani G, Spada A. G protein mutations in endocrine diseases. Eur J Endocrinol. 2001 Nov;145(5):543-59. PMID:11720871
  4. ↑ Moreno-Velasquez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in beta-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: AAC.00710-17. doi:, 10.1128/AAC.00710-17. Print 2017 Oct. PMID:28760907 doi:http://dx.doi.org/10.1128/AAC.00710-17
  5. ↑ Tu C, Zhou X, Tropea JE, Austin BP, Waugh DS, Court DL, Ji X. Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14843-8. Epub 2009 Aug 17. PMID:19706445
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