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NADPH-Cytochrome P450 Reductase

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== Structural highlights ==
== Structural highlights ==
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P450r electron transfer cofactors: <scene name='43/436100/Cv/3'>FMN, FAD, NADPH are all in proximity</scene><ref>PMID:21808038</ref>.
+
P450r electron transfer cofactors: <scene name='43/436100/Cv/18'>FMN, FAD, NADPH are all in proximity</scene><ref>PMID:21808038</ref>.
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*<scene name='43/436100/Cv/5'>NADP binding site</scene>. Water molecule shown as red spheres.
+
*<scene name='43/436100/Cv/19'>NADP binding site</scene>. Water molecule are shown as red spheres.
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*<scene name='43/436100/Cv/16'>FAD/NADP connection via Thr538 and water molecule</scene>.
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*<scene name='43/436100/Cv/20'>FAD/NADP connection via Thr538 and water molecule</scene>.
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*<scene name='43/436100/Cv/17'>FAD binding site</scene>.
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*<scene name='43/436100/Cv/21'>FAD binding site</scene>.
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*<scene name='43/436100/Cv/13'>FAD and FMN are also in proximity</scene>.
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*<scene name='43/436100/Cv/22'>FAD and FMN are also in proximity</scene>.
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*<scene name='43/436100/Cv/12'>FMN binding site</scene>.
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*<scene name='43/436100/Cv/23'>FMN binding site</scene>.
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*<scene name='43/436100/Cv/14'>NADP and FAD are in pockets, while FMN is in tunnel</scene>.
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*<scene name='43/436100/Cv/24'>NADP and FAD are in pockets, while FMN is in tunnel</scene>.
</StructureSection>
</StructureSection>
== 3D Structures of NADPH-Cytochrome P450 Reductase ==
== 3D Structures of NADPH-Cytochrome P450 Reductase ==

Revision as of 12:49, 22 July 2019

Human NADPH-Cytochrome P450 reductase FMN-binding and FAD/NADPH domains complex with FMN, FAD, NADP and Ca+2 ion (green) (PDB entry 3qe2)

Drag the structure with the mouse to rotate

3D Structures of NADPH-Cytochrome P450 Reductase

Updated on 22-July-2019

References

  1. ↑ Hamdane D, Xia C, Im SC, Zhang H, Kim JJ, Waskell L. Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450. J Biol Chem. 2009 Apr 24;284(17):11374-84. Epub 2009 Jan 26. PMID:19171935 doi:10.1074/jbc.M807868200
  2. ↑ Pandey AV, Fluck CE. NADPH P450 oxidoreductase: structure, function, and pathology of diseases. Pharmacol Ther. 2013 May;138(2):229-54. doi: 10.1016/j.pharmthera.2013.01.010., Epub 2013 Jan 24. PMID:23353702 doi:http://dx.doi.org/10.1016/j.pharmthera.2013.01.010
  3. ↑ Xia C, Panda SP, Marohnic CC, Martasek P, Masters BS, Kim JJ. Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13486-91. Epub 2011 Aug 1. PMID:21808038 doi:10.1073/pnas.1106632108

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