Nitroreductase

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Revision as of 14:03, 23 July 2019

E. coli nitroreductase dimer containing FMN and nicotinic acid (PDB entry 1icr)

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Updated on 23-July-2019

↑ Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001 May 25;309(1):203-13. PMID:11491290 doi:10.1006/jmbi.2001.4653
↑ Williams EM, Little RF, Mowday AM, Rich MH, Chan-Hyams JV, Copp JN, Smaill JB, Patterson AV, Ackerley DF. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility. Biochem J. 2015 Oct 15;471(2):131-53. doi: 10.1042/BJ20150650. PMID:26431849 doi:http://dx.doi.org/10.1042/BJ20150650

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 == Structural highlights ==
-NR <scene name='48/489319/Cv/2'>cofactor FMN is bound directly to one subunit</scene> while the <scene name='48/489319/Cv/3'>ligand - nicotinic acid - interacts with both subunits</scene>. Water molecules shown as red spheres.
+NR <scene name='48/489319/Cv/4'>cofactor FMN is bound directly to one subunit</scene> while the <scene name='48/489319/Cv/5'>ligand - nicotinic acid - interacts with both subunits</scene>. Water molecules are shown as red spheres.
 </StructureSection>