5zxe
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of a consensus sequence derived from the FGF family== | |
| + | <StructureSection load='5zxe' size='340' side='right'caption='[[5zxe]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5zxe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXE FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxe OCA], [http://pdbe.org/5zxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxe RCSB], [http://www.ebi.ac.uk/pdbsum/5zxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxe ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCgamma pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. Future applications of FGFs are expected when the biological functions of FGFs are potentiated through the appropriate use of delivery systems and scaffolds. This review will introduce the biology and cellular functions of FGFs and deal with the biomaterials based delivery systems and their current applications for the regeneration of tissues, including skin, blood vessel, muscle, adipose, tendon/ligament, cartilage, bone, tooth, and nerve tissues. | ||
| - | + | Fibroblast growth factors: biology, function, and application for tissue regeneration.,Yun YR, Won JE, Jeon E, Lee S, Kang W, Jo H, Jang JH, Shin US, Kim HW J Tissue Eng. 2010 Nov 7;2010:218142. doi: 10.4061/2010/218142. PMID:21350642<ref>PMID:21350642</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5zxe" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gosavi, S]] | [[Category: Gosavi, S]] | ||
| - | [[Category: Ramaswamy, S]] | ||
| - | [[Category: Tripathi, S.K]] | ||
[[Category: Mandalaparthy, V]] | [[Category: Mandalaparthy, V]] | ||
| + | [[Category: Ramaswamy, S]] | ||
| + | [[Category: Tripathi, S K]] | ||
| + | [[Category: Basic form]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Fgf]] | ||
Revision as of 06:04, 24 July 2019
Structure of a consensus sequence derived from the FGF family
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