6mr4
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Sth1 bromodomain from S.cerevisiae== | |
| - | + | <StructureSection load='6mr4' size='340' side='right'caption='[[6mr4]], [[Resolution|resolution]] 2.71Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mr4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MR4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mr4 OCA], [http://pdbe.org/6mr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mr4 RCSB], [http://www.ebi.ac.uk/pdbsum/6mr4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mr4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STH1_YEAST STH1_YEAST]] Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.<ref>PMID:10025404</ref> <ref>PMID:10320476</ref> <ref>PMID:10329629</ref> <ref>PMID:12072455</ref> <ref>PMID:12183366</ref> <ref>PMID:12697820</ref> <ref>PMID:8980231</ref> <ref>PMID:9799253</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: DNA helicase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Blus, B J]] | ||
| + | [[Category: Debler, E W]] | ||
| + | [[Category: Hashimoto, H]] | ||
| + | [[Category: Krolak, A]] | ||
| + | [[Category: Seo, H S]] | ||
| + | [[Category: Acetylated-lysine histone binding]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Chromatin structure]] | ||
| + | [[Category: Gene expression]] | ||
| + | [[Category: Gene regulation]] | ||
Revision as of 06:15, 24 July 2019
Crystal structure of the Sth1 bromodomain from S.cerevisiae
| |||||||||||
