6nf2

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m (Protected "6nf2" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6nf2 is ON HOLD
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==Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122==
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<StructureSection load='6nf2' size='340' side='right'caption='[[6nf2]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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Authors: Gorman, J., Kwong, P.D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nf2]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NF2 FirstGlance]. <br>
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Description: Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6mqc|6mqc]]</td></tr>
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[[Category: Kwong, P.D]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nf2 OCA], [http://pdbe.org/6nf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nf2 RCSB], [http://www.ebi.ac.uk/pdbsum/6nf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nf2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Gorman, J]]
[[Category: Gorman, J]]
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[[Category: Kwong, P D]]
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[[Category: Fp]]
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[[Category: Fusion peptide]]
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[[Category: Hiv-1]]
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[[Category: Immune system]]
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[[Category: Sosip]]
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[[Category: Vaccine]]

Revision as of 06:17, 24 July 2019

Cryo-EM structure of vaccine-elicited antibody 0PV-c.01 in complex with HIV-1 Env BG505 DS-SOSIP and antibodies VRC03 and PGT122

PDB ID 6nf2

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