6oif
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human TorsinA filament== | |
| - | + | <StructureSection load='6oif' size='340' side='right'caption='[[6oif]], [[Resolution|resolution]] 4.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6oif]] is a 25 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OIF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OIF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oif OCA], [http://pdbe.org/6oif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oif RCSB], [http://www.ebi.ac.uk/pdbsum/6oif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oif ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TOR1A_HUMAN TOR1A_HUMAN]] Myoclonus-dystonia syndrome;Early-onset generalized limb-onset dystonia. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TOR1A_HUMAN TOR1A_HUMAN]] Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.<ref>PMID:15505207</ref> <ref>PMID:16361107</ref> <ref>PMID:17428918</ref> <ref>PMID:18167355</ref> <ref>PMID:18827015</ref> <ref>PMID:19339278</ref> <ref>PMID:20169475</ref> <ref>PMID:23569223</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Demircioglu, F E]] | ||
| + | [[Category: Egelman, E H]] | ||
| + | [[Category: Schwartz, T U]] | ||
| + | [[Category: Zheng, W]] | ||
| + | [[Category: Aaa+ atpase]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Nuclear envelope]] | ||
| + | [[Category: Nucleotide binding]] | ||
Revision as of 06:20, 24 July 2019
Cryo-EM structure of human TorsinA filament
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