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6pnn

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m (Protected "6pnn" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6pnn is ON HOLD
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==Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)acetamide==
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<StructureSection load='6pnn' size='340' side='right'caption='[[6pnn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors: Oakley, A.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6pnn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PNN FirstGlance]. <br>
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Description: Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)acetamide
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OR7:2-chloro-N-{4-chloro-3-[(2-methoxyethyl)(methyl)sulfamoyl]phenyl}acetamide'>OR7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pnn OCA], [http://pdbe.org/6pnn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pnn RCSB], [http://www.ebi.ac.uk/pdbsum/6pnn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pnn ProSAT]</span></td></tr>
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[[Category: Oakley, A.J]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Oakley, A J]]
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[[Category: Glutathione transferase]]
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[[Category: Inhibitor]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 06:26, 24 July 2019

Human GSTO1-1 complexed with 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)acetamide

PDB ID 6pnn

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