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2rki

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Revision as of 06:42, 24 April 2008

Image:2rki.jpg

Template:STRUCTURE 2rki

Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI


Overview

A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.

About this Structure

2RKI is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis., Kirschberg TA, Balakrishnan M, Huang W, Hluhanich R, Kutty N, Liclican AC, McColl DJ, Squires NH, Lansdon EB, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1131-4. Epub 2007 Dec 5. PMID:18083512 Page seeded by OCA on Thu Apr 24 09:42:46 2008

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