2rki
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Revision as of 06:42, 24 April 2008
Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with a triazole derived NNRTI
Overview
A series of 3,4,5-trisubstituted 1,2,4-4H triazole derivatives was synthesized and investigated for HIV-1 reverse transcriptase inhibition. An X-ray structure with HIV-1 RT secured the binding mode and allowed the key interactions with the enzyme to be identified.
About this Structure
2RKI is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis., Kirschberg TA, Balakrishnan M, Huang W, Hluhanich R, Kutty N, Liclican AC, McColl DJ, Squires NH, Lansdon EB, Bioorg Med Chem Lett. 2008 Feb 1;18(3):1131-4. Epub 2007 Dec 5. PMID:18083512 Page seeded by OCA on Thu Apr 24 09:42:46 2008
Categories: Human immunodeficiency virus 1 | Protein complex | RNA-directed DNA polymerase | Kirschberg, T A. | Lansdon, E B. | Aid | Aspartyl protease | Capsid maturation | Core protein | Cytoplasm | Dna integration | Dna recombination | Dna-directed dna polymerase | Endonuclease | Hiv-1 | Host-virus interaction | Hydrolase | Lipoprotein | Magnesium | Membrane | Metal-binding | Multifunctional enzyme | Myristate | Nnrti | Non-nucleoside reverse transcriptase inhibitor | Nuclease | Nucleotidyltransferase | Nucleus | Phosphorylation | Polymerase | Protease | Reverse transcriptase | Rna-binding | Rna-directed dna polymerase | Rnase h | Rt | Transferase | Viral nucleoprotein | Virion | Virus | Zinc | Zinc-finger
