6od9

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6od9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od9 OCA], [http://pdbe.org/6od9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6od9 RCSB], [http://www.ebi.ac.uk/pdbsum/6od9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6od9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6od9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od9 OCA], [http://pdbe.org/6od9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6od9 RCSB], [http://www.ebi.ac.uk/pdbsum/6od9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6od9 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Riboswitches are conformationally dynamic RNAs that regulate gene expression by binding specific small molecules. ZTP riboswitches bind the purine-biosynthetic intermediate 5-aminoimidazole-4-carboxamide riboside 5'-monophosphate (ZMP) and its triphosphorylated form (ZTP). Ligand binding to this riboswitch ultimately upregulates genes involved in folate and purine metabolism. Using an X-ray free-electron laser (XFEL), the room-temperature structure of the Fusobacterium ulcerans ZTP riboswitch bound to ZMP has now been determined at 4.1 A resolution. This model, which was refined against a data set from approximately 750 diffraction images (each from a single crystal), was found to be consistent with that previously obtained from data collected at 100 K using conventional synchrotron X-radiation. These experiments demonstrate the feasibility of time-resolved XFEL experiments to understand how the ZTP riboswitch accommodates cognate ligand binding.
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Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser.,Jones C, Tran B, Conrad C, Stagno J, Trachman R 3rd, Fischer P, Meents A, Ferre-D'Amare A Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):496-500. doi:, 10.1107/S2053230X19008549. Epub 2019 Jun 28. PMID:31282869<ref>PMID:31282869</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6od9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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Revision as of 08:41, 24 July 2019

Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser

PDB ID 6od9

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