Hirudin
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The <scene name='41/417483/Cv/4'>N-terminal tripeptide of hirudin (green) binds to the heavy chain of thrombin (magenta) and interacts with two of its active site residues: Ser195 and His57</scene><ref>PMID:1920434</ref>. | The <scene name='41/417483/Cv/4'>N-terminal tripeptide of hirudin (green) binds to the heavy chain of thrombin (magenta) and interacts with two of its active site residues: Ser195 and His57</scene><ref>PMID:1920434</ref>. | ||
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| + | == 3D Structures of Hirudin == | ||
| + | [[Hirudin 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
== 3D Structures of Hirudin == | == 3D Structures of Hirudin == | ||
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**[[1fph]], [[7kme]], [[1d6w]] - Hirg +hThr L&H chains+polypeptide<br /> | **[[1fph]], [[7kme]], [[1d6w]] - Hirg +hThr L&H chains+polypeptide<br /> | ||
**[[1hxe]] - Hirg +hThr L&H chains+Rb<br /> | **[[1hxe]] - Hirg +hThr L&H chains+Rb<br /> | ||
| - | **[[1ypk]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1no9]], [[1oyt]], [[1o2g]], [[1ny2]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1h8i]], [[1h8d]], [[1c5n]], [[1c5o]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qbv]], [[1bcu]], [[1a2c]], [[1a61]], [[1a46]], [[1a5g]], [[1b5g]], [[1ad8]], [[1ai8]], [[1tom]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[3hat]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[1tmb]], [[3f68]], [[3eq0]], [[3dt0]], [[3dux]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2pw8]], [[3c27]], [[2r2m]], [[2cf8]], [[2cf9]], [[2bdy]], [[2v3h]], [[2v3o]], [[1w7g]], [[1ype]], [[1ypg]], [[1ypj]], [[3biu]], [[3biv]], [[1doj]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1k21]], [[1k22]], [[1afe]], [[1ae8]] ,[[1a3b]], [[1a3e]], [[1vr1]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bxt]], [[2bxu]], [[2gde]], [[2pks]], [[3ldx]], [[3p17]], [[1d9i]], [[1xm1]], [[6eo8]], [[6eo9]], [[1ba8]], [[1bb0]], [[1c4u]], [[1ca8]], [[1d3d]], [[1d3p]], [[1d3q]], [[1d3t]], [[1d4p]], [[1hdt]], [[1ihs]], [[1iht]], [[1o0d]], [[1qhr]], [[1tbz]], [[4ayv]], [[4ayy]], [[4az2]], [[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]], [[3qtv]], [[3qwc]], [[3qx5]], [[4yes]] – Hirg+ hThr L&H chains+inhibitor<br /> | + | **[[1ypk]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1no9]], [[1oyt]], [[1o2g]], [[1ny2]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1h8i]], [[1h8d]], [[1c5n]], [[1c5o]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qbv]], [[1bcu]], [[1a2c]], [[1a61]], [[1a46]], [[1a5g]], [[1b5g]], [[1ad8]], [[1ai8]], [[1tom]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[3hat]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[1tmb]], [[3f68]], [[3eq0]], [[3dt0]], [[3dux]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2pw8]], [[3c27]], [[2r2m]], [[2cf8]], [[2cf9]], [[2bdy]], [[2v3h]], [[2v3o]], [[1w7g]], [[1ype]], [[1ypg]], [[1ypj]], [[3biu]], [[3biv]], [[1doj]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1k21]], [[1k22]], [[1afe]], [[1ae8]] ,[[1a3b]], [[1a3e]], [[1vr1]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bxt]], [[2bxu]], [[2gde]], [[2pks]], [[3ldx]], [[3p17]], [[1d9i]], [[1xm1]], [[6eo8]], [[6eo9]], [[1ba8]], [[1bb0]], [[1c4u]], [[1ca8]], [[1d3d]], [[1d3p]], [[1d3q]], [[1d3t]], [[1d4p]], [[1hdt]], [[1ihs]], [[1iht]], [[1o0d]], [[1qhr]], [[1tbz]], [[4ayv]], [[4ayy]], [[4az2]], [[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]], [[3qtv]], [[3qwc]], [[3qx5]], [[4yes]], [[6gbw]], [[6fjt]] – Hirg+ hThr L&H chains+inhibitor<br /> |
**[[2feq]], [[2fes]] – Hirg analog + hThr L&H chains+inhibitor<br /> | **[[2feq]], [[2fes]] – Hirg analog + hThr L&H chains+inhibitor<br /> | ||
**[[3sha]], [[3shc]], [[3si3]], [[3si4]], [[3sv2]], [[3t5f]], [[3u98]], [[3u9a]], [[3uwj]], [[4ban]], [[4bao]], [[4e7r]], [[4loy]], [[5lpd]], [[5mjt]], [[5mls]], [[5mm6]], [[5ahg]], [[5afz]], [[5afy]], [[5af9]], [[5a2m]], [[4ufg]], [[4uff]], [[4ufe]], [[4ufd]], [[4ueh]], [[4ue7]], [[4udw]], [[4ud9]] – Hirg variant 2 + hThr L&H chains+inhibitor<br /> | **[[3sha]], [[3shc]], [[3si3]], [[3si4]], [[3sv2]], [[3t5f]], [[3u98]], [[3u9a]], [[3uwj]], [[4ban]], [[4bao]], [[4e7r]], [[4loy]], [[5lpd]], [[5mjt]], [[5mls]], [[5mm6]], [[5ahg]], [[5afz]], [[5afy]], [[5af9]], [[5a2m]], [[4ufg]], [[4uff]], [[4ufe]], [[4ufd]], [[4ueh]], [[4ue7]], [[4udw]], [[4ud9]] – Hirg variant 2 + hThr L&H chains+inhibitor<br /> | ||
Revision as of 09:04, 25 July 2019
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3D Structures of Hirudin
Updated on 25-July-2019
References
- ↑ Fenton JW 2nd, Ofosu FA, Brezniak DV, Hassouna HI. Thrombin and antithrombotics. Semin Thromb Hemost. 1998;24(2):87-91. PMID:9579630 doi:http://dx.doi.org/10.1055/s-2007-995828
- ↑ Stamenova PK, Marchetti T, Simeonov I. Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2001 Mar-Apr;5(2):37-42. PMID:11863317
- ↑ Johnson PH. Hirudin: clinical potential of a thrombin inhibitor. Annu Rev Med. 1994;45:165-77. PMID:8198374 doi:http://dx.doi.org/10.1146/annurev.med.45.1.165
- ↑ Rydel TJ, Tulinsky A, Bode W, Huber R. Refined structure of the hirudin-thrombin complex. J Mol Biol. 1991 Sep 20;221(2):583-601. PMID:1920434
