Histone acetyltransferase
From Proteopedia
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| - | == 3D Structures of histone acetyltransferase == | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Histone acetyltransferase; Human domains – HAT 170-458; catalytic 497-662; bromodomain 729-837; | ||
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| - | **[[1f68]] – hHAT bromodomain (mutant) – human – NMR | ||
| - | |||
| - | **[[1n72]] - hHAT bromodomain – NMR | ||
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| - | **[[3d7c]] - hHAT bromodomain | ||
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| - | **[[3gg3]] - hHAT PCAF bromodomain | ||
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| - | **[[2ou2]] - hHAT HTATIP<br /> | ||
| - | **[[2eko]] – hHAT HTATIP histone tail-binding domain - NMR | ||
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| - | **[[1z4r]] – hHAT catalytic domain<br /> | ||
| - | **[[3toa]] - hHAT Myst1 HAT domain<br /> | ||
| - | **[[3tob]] - hHAT Myst1 HAT domain (mutant)<br /> | ||
| - | **[[2rc4]] – hHAT Myst3 acetyltransferase domain<br /> | ||
| - | **[[5trm]] - hHAT KAT2A catalytic domain <br /> | ||
| - | **[[4nsq]] - hHAT KAT2B<br /> | ||
| - | **[[4qqg]] - hHAT KAT5 N terminal<br /> | ||
| - | **[[2ln0]] - hHAT KAT6A<br /> | ||
| - | **[[4ljn]] - hHAT KAT6A double PHD finger<br /> | ||
| - | **[[5wci]] - hHAT KAT8 HAT domain <br /> | ||
| - | **[[5j8c]], [[5j8f]] - hHAT KAT8 HAT domain (mutant)<br /> | ||
| - | **[[1qso]] - yHAT HPA2 – yeast<br /> | ||
| - | **[[3to7]] – yHAT Esa1<br /> | ||
| - | **[[2rnz]] – yHAT Esa1 chromodomain – NMR | ||
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| - | **[[2ro0]] - yHAT Esa1 knotted Tudor domain – NMR<br /> | ||
| - | **[[1ygh]] – yHAT HAT domain<br /> | ||
| - | **[[2qec]] – HAT HPA2 (mutant) – ''Corynebacterium glutamicum''<br /> | ||
| - | **[[6ia8]], [[6iad]], [[6iaz]] - HAT – ''Methanocaldococcus infernus''<br /> | ||
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| - | *Histone acetyltransferase binary complexes | ||
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| - | **[[1wug]], [[1wum]] – hHAT PCAF + small ligand | ||
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| - | **[[1zs5]] – hHAT bromodomain + inhibitor – NMR | ||
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| - | **[[2ozu]] - hHAT MYST3 catalytic domain + acetyl-CoA | ||
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| - | **[[2p0w]] - hHAT 1 catalytic domain + histone H4 peptide | ||
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| - | **[[2rnw]], [[2rnx]] - hHAT PCAF bromodomain + histone H3 peptide - NMR<br /> | ||
| - | **[[5h84]] - hHAT KAT2A catalytic domain + propionyl CoA<br /> | ||
| - | **[[5h86]] - hHAT KAT2A catalytic domain + butyryl CoA<br /> | ||
| - | **[[5trl]] - hHAT KAT2A catalytic domain + succinyl CoA<br /> | ||
| - | **[[5mlj]], [[6j3p]] - hHAT KAT2A bromodomain + inhibitor<br /> | ||
| - | **[[5lvq]], [[5lvr]], [[5fdz]], [[5fe0]], [[5fe1]], [[5fe2]], [[5fe3]], [[5fe4]], [[5fe5]], [[5fe6]], [[5fe7]], [[5fe8]], [[5fe9]], [[5mkx]] - hHAT KAT2B bromodomain + inhibitor<br /> | ||
| - | **[[4dnc]] – hHAT KAT8 HAT domain + male-specific lethal 1 homolog<br /> | ||
| - | **[[3v43]], [[4lk9]], [[4lka]], [[4llb]], [[5b75]], [[5b76]], [[5b77]], [[5b78]] - hHAT KAT6A + H3.1 peptide<br /> | ||
| - | **[[5u2j]] - hHAT KAT6B + H3K14BU peptide<br /> | ||
| - | **[[5gk9]] - hHAT KAT7 + BRD1<br /> | ||
| - | **[[5ml0]] - HAT KAT2B bromodomain + inhibitor - mouse<br /> | ||
| - | **[[1bob]] – yHAT 1 + acetyl-CoA | ||
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| - | **[[1qsm]] – yHAT HPA2 + acetyl-CoA | ||
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| - | **[[1fy7]], [[1mja]] - yHAT Esa1 + CoA<br /> | ||
| - | **[[3to6]] - yHAT Esa1 + H4 peptide<br /> | ||
| - | **[[4psw]] - yHAT B + H4 peptide<br /> | ||
| - | **[[1e6i]] - yHAT bromodomain + H4 peptide<br /> | ||
| - | **[[1mj9]], [[3to9]] - yHAT Esa1 (mutant) + CoA | ||
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| - | **[[1mjb]] - yHAT Esa1 (mutant) + acetyl-CoA | ||
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| - | **[[3qm0]] - yHAT RTT109 (mutant) + acetyl-CoA | ||
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| - | **[[3q35]], [[3q66]], [[3q68]] – yHAT RTT109 + vacuolar protein sorting-associated protein 75 | ||
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| - | **[[5gcn]] – TtHAT Gcn5 + CoA – ''Tetrahymena thermophila'' - NMR<br /> | ||
| - | **[[5tpx]] - HAT GCN5 + probe – ''Plasmodium falciparum''<br /> | ||
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| - | *Histone acetyltransferase ternary complexes | ||
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| - | **[[3q33]] – yHAT RTT109 + vacuolar protein sorting-associated protein 75 + histone H3 peptide<br /> | ||
| - | **[[4psx]] - yHAT B + H3 peptide + H4 peptide<br /> | ||
| - | **[[5j9q]], [[5j9t]], [[5j9u]], [[5j9w]] - yHAT Esa1 (mutant) + chromatin modification-related protein + enhancer of polycomb-like protein<br /> | ||
| - | **[[6cw3]], [[6cw2]] - yHAT GCN5 residues 67-316 + transcriptional adaptor + antibody<br /> | ||
| - | **[[1q2c]] - TtHAT Gcn5 + CoA + histone H4 peptide | ||
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| - | **[[1q2d]] - TtHAT Gcn5 + CoA + p53 peptide | ||
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| - | * Histone acetyltransferase P300; domains – core domain residues 1043-1519; bromodomain residues 1040-1161; acetyltransferase domain residues 1287-1664; TAZ2 domain 1723-1836: | ||
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| - | **[[3i3j]] – hHAT P300 bromodomain <br /> | ||
| - | **[[3io2]] – hHAT P300 TAZ2 domain <br /> | ||
| - | **[[4bhw]] - hHAT P300 core (mutant)<br /> | ||
| - | **[[6k4n]] - hHAT P300 bromodomain+acetyltransferase domains – Cryo EM<br /> | ||
| - | **[[2mh0]] - hHAT P300 TAZ2 + transcription factor ITF-1<br /> | ||
| - | **[[2mh0]], [[2k8f]] - hHAT P300 TAZ2 (mutant) + p53 peptide<br /> | ||
| - | **[[4pzr]], [[4pzs]] - hHAT P300 acetyltransferase domain (mutant) + acetyl CoA<br /> | ||
| - | **[[4pzt]] - hHAT P300 acetyltransferase domain (mutant) + acetonyl CoA<br /> | ||
| - | **[[5lkt]] - hHAT P300 residues 1581-1666 + butyryl CoA<br /> | ||
| - | **[[5lku]] - hHAT P300 core + CoA<br /> | ||
| - | **[[5lkx]] - hHAT P300 core (mutant) + propionyl CoA<br /> | ||
| - | **[[5lkz]] - hHAT P300 core (mutant) + crotonyl CoA<br /> | ||
| - | **[[3biy]] – hHAT P300 acetyltransferase domain + lysine CoA derivative<br /> | ||
| - | **[[5kj2]] - hHAT P300 acetyltransferase domain + inhibitor<br /> | ||
| - | **[[6gyr]] - hHAT P300 core+acetyltransferase domains + lysine CoA derivative<br /> | ||
| - | **[[5xzc]] - hHAT P300 core+acetyltransferase domains + p53<br /> | ||
| - | **[[5bt3]], [[5nu5]], [[5lpk]], [[5lpm]] - hHAT P300 bromodomain + inhibitor<br /> | ||
| - | **[[6gyt]] - hHAT P300 bromodomain + histone H4 peptide<br /> | ||
| - | **[[3p57]] - hHAT P300 TAZ2 domain + myocyte-specific enhancer factor 2A + DNA | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:25, 28 July 2019
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References
- ↑ Roth SY, Denu JM, Allis CD. Histone acetyltransferases. Annu Rev Biochem. 2001;70:81-120. PMID:11395403 doi:10.1146/annurev.biochem.70.1.81
- ↑ Dekker FJ, van den Bosch T, Martin NI. Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. Drug Discov Today. 2014 May;19(5):654-60. doi: 10.1016/j.drudis.2013.11.012. Epub, 2013 Nov 21. PMID:24269836 doi:http://dx.doi.org/10.1016/j.drudis.2013.11.012
- ↑ Van Beekum O, Kalkhoven E. Aberrant forms of histone acetyltransferases in human disease. Subcell Biochem. 2007;41:233-62. PMID:17484131
- ↑ Dutnall RN, Tafrov ST, Sternglanz R, Ramakrishnan V. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell. 1998 Aug 21;94(4):427-38. PMID:9727486
