6abo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==human XRCC4 and IFFO1 complex== | |
| - | + | <StructureSection load='6abo' size='340' side='right'caption='[[6abo]], [[Resolution|resolution]] 2.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6abo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ABO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ABO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6abo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6abo OCA], [http://pdbe.org/6abo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6abo RCSB], [http://www.ebi.ac.uk/pdbsum/6abo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6abo ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN]] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li, J]] | ||
| + | [[Category: Liang, H]] | ||
| + | [[Category: Liu, L]] | ||
| + | [[Category: Liu, Y]] | ||
| + | [[Category: Xu, D]] | ||
| + | [[Category: Coiled-coil]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Nuclear protein]] | ||
Revision as of 06:08, 31 July 2019
human XRCC4 and IFFO1 complex
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Categories: Large Structures | Li, J | Liang, H | Liu, L | Liu, Y | Xu, D | Coiled-coil | Complex | Nuclear protein
