6mhe

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'''Unreleased structure'''
 
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The entry 6mhe is ON HOLD until Paper Publication
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==Galphai3 co-crystallized with KB752==
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<StructureSection load='6mhe' size='340' side='right'caption='[[6mhe]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Rees, S.D., Kalogriopoulos, N.A., Ngo, T., Kopcho, N., Ilatovskiy, A., Sun, N., Komives, E., Chang, G., Ghosh, P., Kufareva, I.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mhe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MHE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MHE FirstGlance]. <br>
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Description: Galphai3 co-crystallized with KB752
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mhe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mhe OCA], [http://pdbe.org/6mhe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mhe RCSB], [http://www.ebi.ac.uk/pdbsum/6mhe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mhe ProSAT]</span></td></tr>
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[[Category: Rees, S.D]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GNAI3_RAT GNAI3_RAT]] Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:2159473). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.[UniProtKB:P08754]<ref>PMID:2159473</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Chang, G]]
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[[Category: Ghosh, P]]
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[[Category: Ilatovskiy, A]]
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[[Category: Kalogriopoulos, N A]]
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[[Category: Komives, E]]
[[Category: Kopcho, N]]
[[Category: Kopcho, N]]
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[[Category: Kalogriopoulos, N.A]]
 
[[Category: Kufareva, I]]
[[Category: Kufareva, I]]
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[[Category: Chang, G]]
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[[Category: Ngo, T]]
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[[Category: Ilatovskiy, A]]
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[[Category: Rees, S D]]
[[Category: Sun, N]]
[[Category: Sun, N]]
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[[Category: Ngo, T]]
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[[Category: Exchange]]
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[[Category: Ghosh, P]]
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[[Category: Gpcr]]
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[[Category: Komives, E]]
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[[Category: Inhibitory]]
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[[Category: Signaling protein]]

Revision as of 06:20, 31 July 2019

Galphai3 co-crystallized with KB752

PDB ID 6mhe

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