6pik
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tetrameric cryo-EM ArnA== | |
| - | + | <StructureSection load='6pik' size='340' side='right'caption='[[6pik]], [[Resolution|resolution]] 7.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6pik]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PIK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pik OCA], [http://pdbe.org/6pik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pik RCSB], [http://www.ebi.ac.uk/pdbsum/6pik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pik ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A3W2RQG2_ECOLX A0A3W2RQG2_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS01095241] [[http://www.uniprot.org/uniprot/A0A479JW67_ECOLX A0A479JW67_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS01095241] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gehring, K]] | ||
| + | [[Category: Yang, M]] | ||
| + | [[Category: Antibiotic]] | ||
| + | [[Category: Hexamer]] | ||
| + | [[Category: Polymyxin resistance]] | ||
| + | [[Category: Tetramer]] | ||
Revision as of 06:29, 31 July 2019
Tetrameric cryo-EM ArnA
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