Phosphoserine phosphatase

(Difference between revisions)

Revision as of 13:26, 5 August 2019

Human phosphoserine phosphatase dimer complex with serine and phosphate 1l8o

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Updated on 05-August-2019

↑ NEUHAUS FC, BYRNE WL. Metabolism of phosphoserine. II. Purification and properties of O-phosphoserine phosphatase. J Biol Chem. 1959 Jan;234(1):113-21. PMID:13610904
↑ Jaeken J, Detheux M, Fryns JP, Collet JF, Alliet P, Van Schaftingen E. Phosphoserine phosphatase deficiency in a patient with Williams syndrome. J Med Genet. 1997 Jul;34(7):594-6. PMID:9222972
↑ Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. J Biol Chem. 2002 Nov 29;277(48):46651-8. Epub 2002 Sep 3. PMID:12213811 doi:10.1074/jbc.M204866200

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 == Structural highlights ==
-The human PSP overall structure contains a <scene name='48/488517/Cv/2'>large core domain and a smaller 4-helix bundle domain</scene>.  The <scene name='48/488517/Cv/5'>active site</scene> is located in a <scene name='48/488517/Cv/6'>cleft between the 2 domains</scene><ref>PMID:12213811</ref>.
+The human PSP overall structure contains a <scene name='48/488517/Cv/7'>large core domain and a smaller 4-helix bundle domain</scene>. The <scene name='48/488517/Cv/8'>active site</scene> is located in a <scene name='48/488517/Cv/9'>cleft between the 2 domains</scene><ref>PMID:12213811</ref>.
 </StructureSection>
 ==3D structures of phosphoserine phosphatase==