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6aei
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the receptor-activated TRPC5 ion channel== | |
| - | + | <StructureSection load='6aei' size='340' side='right'caption='[[6aei]], [[Resolution|resolution]] 2.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6aei]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AEI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aei OCA], [http://pdbe.org/6aei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aei RCSB], [http://www.ebi.ac.uk/pdbsum/6aei PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aei ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPC5_MOUSE TRPC5_MOUSE]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Duan, J]] | [[Category: Duan, J]] | ||
| + | [[Category: Li, J]] | ||
[[Category: Li, Z]] | [[Category: Li, Z]] | ||
| - | [[Category: Li, J]] | ||
[[Category: Zhang, J]] | [[Category: Zhang, J]] | ||
| + | [[Category: Cryo-em]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Mouse trpc5]] | ||
Revision as of 05:45, 7 August 2019
Cryo-EM structure of the receptor-activated TRPC5 ion channel
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Categories: Large Structures | Duan, J | Li, J | Li, Z | Zhang, J | Cryo-em | Ion channel | Membrane protein | Mouse trpc5
