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6aez

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'''Unreleased structure'''
 
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The entry 6aez is ON HOLD until Aug 07 2020
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==Crystal structure of human CCL5 trimer==
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<StructureSection load='6aez' size='340' side='right'caption='[[6aez]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6aez]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AEZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AEZ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aez OCA], [http://pdbe.org/6aez PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aez RCSB], [http://www.ebi.ac.uk/pdbsum/6aez PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aez ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CCL5_HUMAN CCL5_HUMAN]] Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.<ref>PMID:16791620</ref> <ref>PMID:1380064</ref> <ref>PMID:8525373</ref> <ref>PMID:9516414</ref> <ref>PMID:15923218</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Chen, P J]]
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[[Category: Chen, Y C]]
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[[Category: Li, K M]]
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[[Category: Sue, S C]]
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[[Category: Sun, Y J]]
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[[Category: Zarivach, R]]
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[[Category: Cc-type]]
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[[Category: Ccl5]]
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[[Category: Chemokine]]
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[[Category: Cytokine]]
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[[Category: Dimer]]
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[[Category: Oligomer]]
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[[Category: Rante]]

Revision as of 05:46, 7 August 2019

Crystal structure of human CCL5 trimer

PDB ID 6aez

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