6k5r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6k5r" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6k5r is ON HOLD
+
==Complex of SUMO2 with Phosphorylated viral SIM IE2==
-
 
+
<StructureSection load='6k5r' size='340' side='right'caption='[[6k5r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6k5r]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K5R FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k5r OCA], [http://pdbe.org/6k5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k5r RCSB], [http://www.ebi.ac.uk/pdbsum/6k5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k5r ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/SUMO3_HUMAN SUMO3_HUMAN]] Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.<ref>PMID:11451954</ref> <ref>PMID:18538659</ref> [[http://www.uniprot.org/uniprot/VIE2_HCMVA VIE2_HCMVA]] Stimulates viral early and late gene expression and thus play a crucial role in the regulation of productive infection. In addition, activates quiescent cells to reenter the cell cycle and upregulates several E2F-responsive genes, which are responsible for pushing the cell into S phase. In S-phase, inhibits cellular DNA synthesis and blocks further cell cycle progression.<ref>PMID:10516036</ref> <ref>PMID:19812159</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Chatterjee, K S]]
 +
[[Category: Das, R]]
 +
[[Category: Complex]]
 +
[[Category: Protein binding-transcription complex]]

Revision as of 05:52, 7 August 2019

Complex of SUMO2 with Phosphorylated viral SIM IE2

PDB ID 6k5r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6k5r"
Personal tools