6nfu
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.== | |
| - | + | <StructureSection load='6nfu' size='340' side='right'caption='[[6nfu]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6nfu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1EM:(1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL+MYRISTATE'>1EM</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfu OCA], [http://pdbe.org/6nfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfu RCSB], [http://www.ebi.ac.uk/pdbsum/6nfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfu ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cortes, D M]] | ||
| + | [[Category: Cuello, L G]] | ||
| + | [[Category: Guan, L]] | ||
| + | [[Category: Hardy, E]] | ||
| + | [[Category: Jahovic, N]] | ||
[[Category: Parameswaran, H]] | [[Category: Parameswaran, H]] | ||
| - | [[Category: Cuello, L.G]] | ||
| - | [[Category: Jahovic, N]] | ||
| - | [[Category: Hardy, E]] | ||
| - | [[Category: Cortes, D.M]] | ||
| - | [[Category: Guan, L]] | ||
[[Category: Tilegenova, C]] | [[Category: Tilegenova, C]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Membrane transport]] | ||
| + | [[Category: Metal transport]] | ||
| + | [[Category: Potassium channel]] | ||
Revision as of 05:55, 7 August 2019
Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
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