6pa0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the G77A mutant in Sodium Chloride== | |
| - | + | <StructureSection load='6pa0' size='340' side='right'caption='[[6pa0]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6pa0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PA0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pa0 OCA], [http://pdbe.org/6pa0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pa0 RCSB], [http://www.ebi.ac.uk/pdbsum/6pa0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pa0 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Cuello, L G]] | ||
[[Category: Guan, L]] | [[Category: Guan, L]] | ||
| - | [[Category: | + | [[Category: Kcsa]] |
| + | [[Category: Permeation]] | ||
| + | [[Category: Potassium channel]] | ||
| + | [[Category: Protein transport]] | ||
| + | [[Category: Protein transport-immune system complex]] | ||
| + | [[Category: Selectivity]] | ||
Revision as of 06:00, 7 August 2019
Structure of the G77A mutant in Sodium Chloride
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