6rv2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation== |
| - | + | <StructureSection load='6rv2' size='340' side='right'caption='[[6rv2]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6rv2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RV2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rv2 OCA], [http://pdbe.org/6rv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rv2 RCSB], [http://www.ebi.ac.uk/pdbsum/6rv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rv2 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCNK3_HUMAN KCNK3_HUMAN]] pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.<ref>PMID:23169818</ref> <ref>PMID:9312005</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Burgess-Brown, N]] | ||
| + | [[Category: Bushell, S R]] | ||
| + | [[Category: Carpenter, E P]] | ||
| + | [[Category: Chalk, R]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Mukhopadhyay, S M.M]] | ||
| + | [[Category: Pike, A C.W]] | ||
| + | [[Category: Quigley, A]] | ||
| + | [[Category: Rodstrom, K E.J]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Shrestha, L]] | ||
| + | [[Category: Speedman, D]] | ||
| + | [[Category: Tessitore, A]] | ||
| + | [[Category: Venkaya, S]] | ||
| + | [[Category: Zhang, W]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Potassium channel]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 06:06, 7 August 2019
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation
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Categories: Large Structures | Arrowsmith, C H | Bountra, C | Burgess-Brown, N | Bushell, S R | Carpenter, E P | Chalk, R | Edwards, A M | Mukhopadhyay, S M.M | Pike, A C.W | Quigley, A | Rodstrom, K E.J | Structural genomic | Shrestha, L | Speedman, D | Tessitore, A | Venkaya, S | Zhang, W | Membrane protein | Potassium channel | Sgc
