6s29

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m (Protected "6s29" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6s29 is ON HOLD
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==Structure of fission yeast Mis16-Mis19 complex==
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<StructureSection load='6s29' size='340' side='right'caption='[[6s29]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6s29]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S29 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s29 OCA], [http://pdbe.org/6s29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s29 RCSB], [http://www.ebi.ac.uk/pdbsum/6s29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s29 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HAT2_SCHPO HAT2_SCHPO]] Regulatory subunit of the histone acetylase B (HAT-B) complex (By similarity). The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity). Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A (PubMed:15369671, PubMed:24774534, PubMed:24789708, PubMed:25375240). Maintains the deacetylated state of histones specifically in the central core of the centromeres (PubMed:15369671).[UniProtKB:P39984]<ref>PMID:15369671</ref> <ref>PMID:24774534</ref> <ref>PMID:24789708</ref> <ref>PMID:25375240</ref> [[http://www.uniprot.org/uniprot/MIS19_SCHPO MIS19_SCHPO]] Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A (PubMed:24774534, PubMed:24789708, PubMed:25375240). Links mis16 and mis18 to recruit CENP-A through interacting with non-sense-mediated mRNA decay (NMD) factors and the SWI/SNF complex (PubMed:24774534). Links also mis18 with the CCAN/mis6/ctf19 complex to promote CENP-A assembly (PubMed:24789708).<ref>PMID:24774534</ref> <ref>PMID:24789708</ref> <ref>PMID:25375240</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Korntner-Vetter, M]]
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[[Category: Lefevre, S]]
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[[Category: Singleton, M R]]
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[[Category: Cell cycle]]
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[[Category: Centromere mitosis wd40 histone chaperone]]

Revision as of 06:07, 7 August 2019

Structure of fission yeast Mis16-Mis19 complex

PDB ID 6s29

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OCA

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