5lqh
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqh OCA], [http://pdbe.org/5lqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqh RCSB], [http://www.ebi.ac.uk/pdbsum/5lqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqh ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lqh OCA], [http://pdbe.org/5lqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lqh RCSB], [http://www.ebi.ac.uk/pdbsum/5lqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lqh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A four-repeat human telomere DNA sequence without the 3'-end guanine, d[TAGGG(TTAGGG)2 TTAGG] (htel1-DeltaG23) has been found to adopt two distinct two G-quartet antiparallel basket-type G-quadruplexes, TD and KDH(+) in presence of KCl. NMR, CD, and UV spectroscopy have demonstrated that topology of KDH(+) form is distinctive with unique protonated T18A20(+) G5 base triple and other capping structural elements that provide novel insight into structural polymorphism and heterogeneity of G-quadruplexes in general. Specific stacking interactions amongst two G-quartets flanking base triples and base pairs in TD and KDH(+) forms are reflected in 10 K higher thermal stability of KDH(+) . Populations of TD and KDH(+) forms are controlled by pH. The (de)protonation of A20 is the key for pH driven structural transformation of htel1-DeltaG23. Reversibility offers possibilities for its utilization as a conformational switch within different compartments of living cell enabling specific ligand and protein interactions. | ||
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| + | Reversible pH Switch of Two-Quartet G-Quadruplexes Formed by Human Telomere.,Galer P, Wang B, Sket P, Plavec J Angew Chem Int Ed Engl. 2016 Feb 5;55(6):1993-7. doi: 10.1002/anie.201507569., Epub 2016 Jan 6. PMID:26836334<ref>PMID:26836334</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5lqh" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:08, 7 August 2019
A two-quartet G-quadruplex formed by human telomere in KCl solution at pH 5.0
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Categories: Large Structures | Galer, P | Plavec, J | Sket, P | Wang, B | Dna | G-quadruplex | Human telomere repeat | Topology
