3c0t

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Revision as of 06:51, 24 April 2008

Image:3c0t.jpg

Template:STRUCTURE 3c0t

Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18


Overview

A combination of crystallography, biochemistry, and gene expression analysis identifies the coactivator subcomplex Med8C/18/20 as a functionally distinct submodule of the Mediator head module. Med8C forms a conserved alpha-helix that tethers Med18/20 to the Mediator. Deletion of Med8C in vivo results in dissociation of Med18/20 from Mediator and in loss of transcription activity of extracts. Deletion of med8C, med18, or med20 causes similar changes in the yeast transcriptome, establishing Med8C/18/20 as a predominantly positive, gene-specific submodule required for low transcription levels of nonactivated genes, including conjugation genes. The presented structure-based system perturbation is superior to gene deletion analysis of gene regulation.

About this Structure

3C0T is a Protein complex structure of sequences from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structure-system correlation identifies a gene regulatory Mediator submodule., Lariviere L, Seizl M, van Wageningen S, Rother S, van de Pasch L, Feldmann H, Strasser K, Hahn S, Holstege FC, Cramer P, Genes Dev. 2008 Apr 1;22(7):872-877. PMID:18381891 Page seeded by OCA on Thu Apr 24 09:51:25 2008

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