Pleurotolysin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus ostreatus''. PTL is a two-component cytolysin composed of non-associated PTL A (17kDa) and PTL B (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis<ref>PMID:15084605</ref>. <scene name='75/751804/Cv/ | + | '''Pleurotolysin''' (PTL) is a pore-forming cytolysin from ''Pleurotus ostreatus''. PTL is a two-component cytolysin composed of non-associated PTL A (17kDa) and PTL B (59kDa) which cooperatively cause leakage of potassium ions from human erythrocytes and swelling of the cells leading to colloid-osmotic hemolysis<ref>PMID:15084605</ref>. <scene name='75/751804/Cv/3'>Pleurotoxin A complex with pleurotoxin B</scene> ([[4v3a]]). |
</StructureSection> | </StructureSection> | ||
Revision as of 12:41, 8 August 2019
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3D structures of pleurotolysin
Updated on 08-August-2019
References
- ↑ Tomita T, Noguchi K, Mimuro H, Ukaji F, Ito K, Sugawara-Tomita N, Hashimoto Y. Pleurotolysin, a novel sphingomyelin-specific two-component cytolysin from the edible mushroom Pleurotus ostreatus, assembles into a transmembrane pore complex. J Biol Chem. 2004 Jun 25;279(26):26975-82. Epub 2004 Apr 14. PMID:15084605 doi:http://dx.doi.org/10.1074/jbc.M402676200
