This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Porphobilinogen synthase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 7: Line 7:
== Structural highlights ==
== Structural highlights ==
-
The biological assembly of Yeast porphobilinogen synthase is <scene name='52/526179/Cv/2'>homooctamer</scene>. The <scene name='52/526179/Cv/3'>active site of PBS contains the substrate laevulinic acid and Zn+2 ion</scene><ref>PMID:11545591</ref>. Water molecules shown as red spheres.
+
The biological assembly of Yeast porphobilinogen synthase is <scene name='52/526179/Cv/4'>homooctamer</scene>. The <scene name='52/526179/Cv/5'>active site of PBS contains the substrate laevulinic acid and Zn+2 ion</scene><ref>PMID:11545591</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>

Revision as of 13:39, 12 August 2019

Yeast porphobilinogen synthase complex with laevulunic acid and Zn+2 ion (grey) (PDB entry 1h7n)

Drag the structure with the mouse to rotate

3D structures of porphobilinogen synthase

Updated on 12-August-2019

References

  1. ↑ Jaffe EK. The porphobilinogen synthase catalyzed reaction mechanism. Bioorg Chem. 2004 Oct;32(5):316-25. PMID:15381398 doi:http://dx.doi.org/10.1016/j.bioorg.2004.05.010
  2. ↑ Doss M, Muller WA. Acute lead poisoning in inherited porphobilinogen synthase (delta-aminolevulinic acid dehydrase) deficiency. Blut. 1982 Aug;45(2):131-9. PMID:7104498
  3. ↑ Erskine PT, Newbold R, Brindley AA, Wood SP, Shoolingin-Jordan PM, Warren MJ, Cooper JB. The x-ray structure of yeast 5-aminolaevulinic acid dehydratase complexed with substrate and three inhibitors. J Mol Biol. 2001 Sep 7;312(1):133-41. PMID:11545591 doi:10.1006/jmbi.2001.4947

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Porphobilinogen_synthase"
Personal tools