3c6t

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Revision as of 06:52, 24 April 2008

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Template:STRUCTURE 3c6t

Crystal Structure of HIV Reverse Transcriptase in complex with inhibitor 14

Overview

Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clinical mutations.

About this Structure

3C6T is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations., Tucker TJ, Saggar S, Sisko JT, Tynebor RM, Williams TM, Felock PJ, Flynn JA, Lai MT, Liang Y, McGaughey G, Liu M, Miller M, Moyer G, Munshi V, Perlow-Poehnelt R, Prasad S, Sanchez R, Torrent M, Vacca JP, Wan BL, Yan Y, Bioorg Med Chem Lett. 2008 Mar 25;. PMID:18396399 Page seeded by OCA on Thu Apr 24 09:52:35 2008