6j0y
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Yeast Rtt107 and Slx4== | |
| - | + | <StructureSection load='6j0y' size='340' side='right'caption='[[6j0y]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6j0y]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J0Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6j0w|6j0w]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0y OCA], [http://pdbe.org/6j0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0y RCSB], [http://www.ebi.ac.uk/pdbsum/6j0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0y ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RT107_YEAST RT107_YEAST]] Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.<ref>PMID:14988729</ref> <ref>PMID:17978089</ref> [[http://www.uniprot.org/uniprot/SLX4_YEAST SLX4_YEAST]] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro. Interacts with the structure-specific RAD1-RAD10 endonuclease and promotes RAD1-RAD10-dependent 3'-non-homologous tail removal (NHTR) during repair of double-strand breaks by single-strand annealing. SLX4 also promotes recovery from DNA-alkylation-induced replisome stalling during DNA replication by facilitating the error-free mode of lesion bypass. This does not require SLX1 or RAD1-RAD10, but probably RTT107.[HAMAP-Rule:MF_03110]<ref>PMID:11139495</ref> <ref>PMID:12228808</ref> <ref>PMID:12832395</ref> <ref>PMID:15834151</ref> <ref>PMID:15975089</ref> <ref>PMID:16267268</ref> <ref>PMID:17636031</ref> <ref>PMID:18471978</ref> <ref>PMID:18579504</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lei, M]] | ||
[[Category: Wan, B]] | [[Category: Wan, B]] | ||
| - | [[Category: Lei, M]] | ||
[[Category: Wu, J]] | [[Category: Wu, J]] | ||
| + | [[Category: Brct domain]] | ||
| + | [[Category: Mitosis]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Protein interaction]] | ||
Revision as of 16:33, 14 August 2019
Crystal Structure of Yeast Rtt107 and Slx4
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