6se4
From Proteopedia
(Difference between revisions)
m (Protected "6se4" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor== | |
| - | + | <StructureSection load='6se4' size='340' side='right'caption='[[6se4]], [[Resolution|resolution]] 1.38Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6se4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SE4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=L8W:(+)-JD1'>L8W</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6se4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6se4 OCA], [http://pdbe.org/6se4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6se4 RCSB], [http://www.ebi.ac.uk/pdbsum/6se4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6se4 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Filippakopoulos, P]] | [[Category: Filippakopoulos, P]] | ||
| - | [[Category: Edwards, A.M]] | ||
| - | [[Category: Arrowsmith, C.H]] | ||
[[Category: Hassell-Hart, S]] | [[Category: Hassell-Hart, S]] | ||
| - | [[Category: Structural Genomics Consortium (Sgc)]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| - | [[Category: Von Delft, F]] | ||
| - | [[Category: Bountra, C]] | ||
[[Category: Picaud, S]] | [[Category: Picaud, S]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Spencer, J]] | ||
| + | [[Category: Brd4]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Bromodomain-containing protein 4 isoform long]] | ||
| + | [[Category: Organometallic bet bromodomain inhibitor]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 16:48, 14 August 2019
Crystal Structure of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor
| |||||||||||
Categories: Large Structures | Arrowsmith, C H | Bountra, C | Delft, F von | Edwards, A M | Filippakopoulos, P | Hassell-Hart, S | Krojer, T | Picaud, S | Structural genomic | Spencer, J | Brd4 | Bromodomain | Bromodomain-containing protein 4 isoform long | Organometallic bet bromodomain inhibitor | Protein binding | Sgc
