Purine nucleoside phosphorylase

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== Structural highlights ==
== Structural highlights ==
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<scene name='57/573714/Cv/2'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/4'>Active site</scene>.
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<scene name='57/573714/Cv/5'>Residues 241-265 of PNP act as a gate that opens upon substrate binding</scene>. The ribose binding site is composed of mostly hydrophobic side chains<ref>PMID:14680831</ref>. <scene name='57/573714/Cv/6'>Active site</scene>.
</StructureSection>
</StructureSection>

Revision as of 13:35, 20 August 2019

Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h)

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3D structures of purine nucleoside phosphorylase

Updated on 20-August-2019

References

  1. ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
  2. ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
  3. ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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