5qt1

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m (Protected "5qt1" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5qt1 is ON HOLD
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==PanDDA analysis group deposition -- Partial occupancy interpretation of PanDDA event map: SETDB1 in complex with FMOMB000017a==
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<StructureSection load='5qt1' size='340' side='right'caption='[[5qt1]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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Authors: Harding, R.J., Tempel, W., DOUANGAMATH, A., BRANDAO-NETO, J., Collins, P.M., Krojer, T., Mader, P., Schapira, M., von Delft, F., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Santhakumar, V.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5qt1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QT1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QT1 FirstGlance]. <br>
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Description: PanDDA analysis group deposition --Partial occupancy interpretation of PanDDA event map: SETDB1 in complex with FMOMB000017a
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DSJ:1-(4-amino-2-hydroxyphenyl)ethan-1-one'>DSJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
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[[Category: Schapira, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qt1 OCA], [http://pdbe.org/5qt1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qt1 RCSB], [http://www.ebi.ac.uk/pdbsum/5qt1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qt1 ProSAT]</span></td></tr>
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[[Category: Edwards, A.M]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Function ==
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[[Category: Brandao-Neto, J]]
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[[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
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[[Category: Santhakumar, V]]
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== References ==
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[[Category: Collins, P.M]]
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<references/>
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[[Category: Douangamath, A]]
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__TOC__
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[[Category: Harding, R.J]]
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</StructureSection>
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[[Category: Histone-lysine N-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: BRANDAO-NETO, J]]
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[[Category: Bountra, C]]
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[[Category: Collins, P M]]
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[[Category: DOUANGAMATH, A]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
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[[Category: Harding, R J]]
[[Category: Krojer, T]]
[[Category: Krojer, T]]
[[Category: Mader, P]]
[[Category: Mader, P]]
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[[Category: Von Delft, F]]
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[[Category: Santhakumar, V]]
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[[Category: Schapira, M]]
[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Bountra, C]]
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[[Category: Pandda]]
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[[Category: Sgc - diamond i04-1 fragment screening]]
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[[Category: Transferase]]
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[[Category: Xchemexplorer]]

Revision as of 05:48, 21 August 2019

PanDDA analysis group deposition -- Partial occupancy interpretation of PanDDA event map: SETDB1 in complex with FMOMB000017a

PDB ID 5qt1

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