6m8h
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the R208Q mutant of G(i) subunit alpha-1== | |
| - | + | <StructureSection load='6m8h' size='340' side='right'caption='[[6m8h]], [[Resolution|resolution]] 2.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6m8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6M8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6m8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m8h OCA], [http://pdbe.org/6m8h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m8h RCSB], [http://www.ebi.ac.uk/pdbsum/6m8h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m8h ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ballicora, M]] | [[Category: Ballicora, M]] | ||
| - | [[Category: De Freitas, D]] | ||
[[Category: Goossens, J]] | [[Category: Goossens, J]] | ||
| + | [[Category: Kothawala, S]] | ||
[[Category: Leverson, B]] | [[Category: Leverson, B]] | ||
| + | [[Category: Liu, D]] | ||
[[Category: Mascarenhas, R]] | [[Category: Mascarenhas, R]] | ||
| + | [[Category: Olsen, K]] | ||
| + | [[Category: Freitas, D de]] | ||
| + | [[Category: G protein]] | ||
| + | [[Category: Oncogenic mutation]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Switch ii region]] | ||
Revision as of 05:54, 21 August 2019
Crystal Structure of the R208Q mutant of G(i) subunit alpha-1
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