2vkz
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ||
==Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex== | ==Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex== | ||
| - | <StructureSection load='2vkz' size='340' side='right' caption='[[2vkz]], [[Resolution|resolution]] 4.00Å' scene=''> | + | <StructureSection load='2vkz' size='340' side='right'caption='[[2vkz]], [[Resolution|resolution]] 4.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vkz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vkz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VKZ FirstGlance]. <br> | ||
| Line 8: | Line 8: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkz OCA], [http://pdbe.org/2vkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vkz RCSB], [http://www.ebi.ac.uk/pdbsum/2vkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkz OCA], [http://pdbe.org/2vkz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vkz RCSB], [http://www.ebi.ac.uk/pdbsum/2vkz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101] [[http://www.uniprot.org/uniprot/FAS1_YEAST FAS1_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. | [[http://www.uniprot.org/uniprot/FAS2_YEAST FAS2_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.[HAMAP-Rule:MF_00101] [[http://www.uniprot.org/uniprot/FAS1_YEAST FAS1_YEAST]] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase. | ||
| Line 15: | Line 14: | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkz_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkz_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 30: | Line 29: | ||
</div> | </div> | ||
<div class="pdbe-citations 2vkz" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2vkz" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Grininger, M]] | [[Category: Grininger, M]] | ||
Revision as of 07:03, 21 August 2019
Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex
| |||||||||||
Categories: Large Structures | Saccharomyces cerevisiae | Grininger, M | Johansson, P | Kessler, B | Kumari, P | Oesterhelt, D | Vonck, J | Vonrhein, C | Wiltschi, B | Cerulenin | Fa | Fatty acid biosynthesis | Fatty acid synthase | Hydrolase | Lipid synthesis | Lyase | Multifunctional enzyme | Nad | Nadp | Oxidoreductase | Phosphopantetheine | Phosphorylation | Transferase
