Hyaluronidase
From Proteopedia
(Difference between revisions)
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<scene name='49/497055/Cv/11'>Dimethylarsinate binding site</scene>. | <scene name='49/497055/Cv/11'>Dimethylarsinate binding site</scene>. | ||
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| + | ==3D structures of hyaluronidase== | ||
| + | [[Hyaluronidase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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*Hyaluronidase | *Hyaluronidase | ||
| + | **[[2pe4]] – HU-1 – human<br /> | ||
| + | **[[1fcq]], [[1fcu]] – bHU – bee<br /> | ||
**[[1egu]], [[2brw]] – SpHU – ''Streptococcus pneumoniae'' <br /> | **[[1egu]], [[2brw]] – SpHU – ''Streptococcus pneumoniae'' <br /> | ||
| + | **[[4d0q]] – SpHU HUA binding domain<br /> | ||
**[[1n7n]], [[1n7o]], [[1n7p]] – SpHU (mutant) <br /> | **[[1n7n]], [[1n7o]], [[1n7p]] – SpHU (mutant) <br /> | ||
| - | **[[1fcq]], [[1fcu]] – bHU – bee<br /> | ||
**[[1f1s]] – SaHU – ''Streptococcus agalactiae'' <br /> | **[[1f1s]] – SaHU – ''Streptococcus agalactiae'' <br /> | ||
**[[2c3f]], [[2dp5]], [[2yw0]], [[2yx2]], [[2wb3]], [[2wh7]] - SpyHU – ''Streptococcus pyogenes''<br /> | **[[2c3f]], [[2dp5]], [[2yw0]], [[2yx2]], [[2wb3]], [[2wh7]] - SpyHU – ''Streptococcus pyogenes''<br /> | ||
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**[[2jnk]] - CpHU residues 1498-1628]] - NMR<br /> | **[[2jnk]] - CpHU residues 1498-1628]] - NMR<br /> | ||
**[[2atm]] - HU – ''Vespula vulgaris''<br /> | **[[2atm]] - HU – ''Vespula vulgaris''<br /> | ||
| - | **[[2pe4]] – HU-1 – human<br /> | ||
**[[4ufq]] – HU – ''Streptomyces koganeiensis''<br /> | **[[4ufq]] – HU – ''Streptomyces koganeiensis''<br /> | ||
*Hyaluronidase binary complex | *Hyaluronidase binary complex | ||
| + | **[[1fcv]] - bHU + HUA<br /> | ||
| + | **[[2j88]] - bHU + FAB<br /> | ||
**[[1c82]] – SpHU + HUA disaccharide <br /> | **[[1c82]] – SpHU + HUA disaccharide <br /> | ||
**[[1f9g]] – SpHU + ascorbate <br /> | **[[1f9g]] – SpHU + ascorbate <br /> | ||
**[[2brv]]– SpHU + malonate<br /> | **[[2brv]]– SpHU + malonate<br /> | ||
| - | **[[1fcv]] - bHU + HUA<br /> | ||
| - | **[[1i8q]] - SaHU + HUA disaccharide <br /> | ||
**[[1loh]], [[1lxk]] - SpHU + glucuronic acid<br /> | **[[1loh]], [[1lxk]] - SpHU + glucuronic acid<br /> | ||
**[[1n7q]], [[1n7r]] - SpHU (mutant) + glucuronic acid<br /> | **[[1n7q]], [[1n7r]] - SpHU (mutant) + glucuronic acid<br /> | ||
| - | **[[1lxm]] - SaHU + glucuronic acid<br /> | ||
**[[1ojm]], [[1ojp]] - SpHU + condroitin disaccharide <br /> | **[[1ojm]], [[1ojp]] - SpHU + condroitin disaccharide <br /> | ||
**[[1ojn]], [[1ojo]] - SpHU (mutant) + condroitin disaccharide <br /> | **[[1ojn]], [[1ojo]] - SpHU (mutant) + condroitin disaccharide <br /> | ||
**[[1w3y]] - SpHU + palmitoyl-vitamin C <br /> | **[[1w3y]] - SpHU + palmitoyl-vitamin C <br /> | ||
| + | **[[2brp]] – SpHU + inhibitor<br /> | ||
| + | **[[1i8q]] - SaHU + HUA disaccharide <br /> | ||
| + | **[[1lxm]] - SaHU + glucuronic acid<br /> | ||
**[[2cbj]] - CpHU + PugNac<br /> | **[[2cbj]] - CpHU + PugNac<br /> | ||
**[[2j1a]] - CpHU + galactose<br /> | **[[2j1a]] - CpHU + galactose<br /> | ||
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**[[2j7m]], [[2w1u]], [[2wdb]] - CpHU + carbohydrates<br /> | **[[2j7m]], [[2w1u]], [[2wdb]] - CpHU + carbohydrates<br /> | ||
**[[2j62]] - CpHU + GlcNac-statin<br /> | **[[2j62]] - CpHU + GlcNac-statin<br /> | ||
| - | **[[2brp]] – SpHU + inbhibitor<br /> | ||
| - | **[[2j88]] - bHU + FAB<br /> | ||
**[[2yvv]] - SpyHU + lactose<br /> | **[[2yvv]] - SpyHU + lactose<br /> | ||
**[[3eka]] - SpyHU + ascorbate <br /> | **[[3eka]] - SpyHU + ascorbate <br /> | ||
Revision as of 10:19, 21 August 2019
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3D structures of hyaluronidase
Updated on 21-August-2019
Reference
- ↑ Chao KL, Muthukumar L, Herzberg O. Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis. Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:17503783 doi:10.1021/bi700382g
- ↑ Ponnuraj K, Jedrzejas MJ. Mechanism of hyaluronan binding and degradation: structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 A resolution. J Mol Biol. 2000 Jun 16;299(4):885-95. PMID:10843845 doi:10.1006/jmbi.2000.3817
Created with the participation of Osnat Herzberg, Eran Hodis, Joel L. Sussman, Jaime Prilusky.
