Rab5 GDP/GTP exchange factor

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== Structural highlights ==
== Structural highlights ==
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The <scene name='68/680139/Cv/3'>rabapin helix packs against the Rasbex5</scene> forming a 3-helix bundle<ref>PMID:9323142</ref>.
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The <scene name='68/680139/Cv/4'>rabapin helix packs against the Rasbex5</scene> forming a 3-helix bundle<ref>PMID:9323142</ref>.
</StructureSection>
</StructureSection>

Revision as of 12:36, 25 August 2019

Human rabex-5 (cyan) complex with rabaptin (green and deeppink) and phosphate ion (PDB code 4n3z).

Drag the structure with the mouse to rotate

3D Structures of Rab5 GDP/GTP exchange factor

Updated on 25-August-2019

1txu – hRabex5 Vps9 domain – human
4n3x – hRabex5 CC domain
2fid, 2fif – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine
2c7m, 2c7n – hRabex5 ubiquitin interacting motif + ubiquitin
2ot3 – hRabex5 Vps9 domain + Ras-related protein Rab21
4n3x – hRabex5 CC domain + Rabaptin
4n3z – hRabex5 5δ + Rabaptin
4q9u – hRabex5 5δ (mutant) + Ras-related protein Rab5A
4n3y – hRabex5 5CC domain + Rab GTPase-binding effector protein


References

  1. Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142
  2. Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142

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