Hydroxysteroid dehydrogenase

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</StructureSection>
</StructureSection>
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==3D structures of hydroxysteroid dehydrogenase==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*3-α HSD or AKR1C2
 
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'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
 
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**[[1ral]] – rHSD – rat<BR />
 
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**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
 
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**[[4is2]] – CsHSD – ''Clostridium scindens''<br />
 
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*''3-α HSD binary complex''
 
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**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
 
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**[[1lwi]] – rHSD + NADP<BR />
 
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**[[1fk8]] – CtHSD + NAD<BR />
 
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**[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR />
 
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**[[4is3]] - CsHSD + NAD<br />
 
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*''3-α HSD ternary complex''
 
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**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
 
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**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
 
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*3-α HSD type 3
 
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**[[2hdj]] - hHSD + NADP<br />
 
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**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />
 
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**[[1xjb]] - hHSD + citrate+ acetate + NADP<br />
 
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**[[4l1w]] - hHSD + progesterone + NADP<br />
 
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**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
 
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**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />
 
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*7-α HSD
 
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**[[3gaf]] - HSD – ''Brucella melitensis''<BR />
 
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**[[1ahh]] – EcHSD + NAD – ''Escherichia coli''<BR />
 
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**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD
 
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*20-α HSD or AKR1C1
 
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**[[1q5m]] - raHSD + NADP – rabbit
 
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*''20-α HSD ternary complex''
 
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**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
 
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**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
 
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**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR />
 
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**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR />
 
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**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
 
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*11-β HSD or corticosteroid 11-β-dehydrogenase 1
 
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**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
 
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**[[2pd6]] - hHSD + NAD<BR />
 
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**[[3hb4]] - hHSD + inhibitor<BR />
 
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**[[3dey]] - hHSD + hydroxysteroid<BR />
 
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**[[1y5m]] - mHSD + NADP - mouse<BR />
 
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**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
 
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**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
 
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*''11-β HSD ternary complex''
 
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**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
 
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**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR />
 
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**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]] - hHSD 1 (mutant) + inhibitor + NADP<BR />
 
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**[[6nj7]] - hHSD 1 + colleic acid + NAP<br />
 
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**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
 
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**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR />
 
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**[[4k26]] - mHSD 1 + inhibitor + NADP<br />
 
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**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
 
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*17-α HSD or AKR1C21
 
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**[[2he8]] – mHSD - mouse <br />
 
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**[[3fjn]] - mHSD (mutant) <br />
 
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**[[2p5n]], [[2he5]], [[2hej]] - mHSD + NADP <br />
 
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**[[2ipf]] - mHSD + hydroxysteroid + NADP <br />
 
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**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />
 
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**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />
 
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*17-β HSD or estradiol 11-β-dehydrogenase 1
 
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'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]
 
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**[[1bhs]] – hHSD 1 <BR />
 
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**[[1s9c]] - hHSD 4 (mutant) <BR />
 
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**[[5ics]] – hHSD 14 <BR />
 
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**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
 
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**[[3itd]] - ClHSD (mutant)
 
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*''17-β HSD binary complex''
 
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**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
 
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**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
 
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**[[6mnc]] – hHSD 1 + estrone<br />
 
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**[[1fdv]] - hHSD 1 (mutant) + NAD<BR />
 
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**[[1qyv]] - hHSD 1 + NADP<BR />
 
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**[[1i5r]], [[6dtp]] - hHSD 1 + inhibitor<br />
 
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**[[1zbq]] - hHSD 4 + NAD<BR />
 
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**[[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD 14 + inhibitor<br />
 
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**[[6h0m]], [[6hno]], [[5js6]], [[5jsf]] - hHSD 14 (mutant) + NAD<br />
 
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**[[3qwf]] - ClHSD + NADP<BR />
 
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**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
 
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*''17-β HSD ternary complex''
 
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**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR />
 
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**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
 
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**[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR />
 
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**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]], [[6cgc]] - hHSD 1 (mutant) + inhibitor + NADP<br />
 
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**[[6mne]] – hHSD 1 + NADP + estrone<br />
 
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**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
 
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**[[5hs6]] - hHSD + NAD + estrone<br />
 
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**[[4cql]] - hHSD 8 + carbonyl reductase + NAD<br />
 
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**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />
 
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**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br />
 
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**[[6ffb]], [[6g4l]], [[6gtu]], [[5o7c]] - hHSD 14 (mutant) + inhibitor + NAD<br />
 
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**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br />
 
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**[[5hs6]] - hHSD 14 + NAD + estrone<br />
 
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**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />
 
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*3-α 20-β HSD
 
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**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
 
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**[[1hdc]] – SeHSD + inhibitor
 
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*Carbonyl reductase/20-β HSD
 
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**[[1n5d]] - HSD + NADP – pig<br />
 
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*3-β/17-β HSD
 
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**[[1hxh ]] - CtHSD
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:57, 27 August 2019

Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP 1lwi

Drag the structure with the mouse to rotate

References

  1. ↑ Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR, Penning TM. Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology. 2003 Jul;144(7):2922-32. PMID:12810547 doi:http://dx.doi.org/10.1210/en.2002-0032
  2. ↑ Haslewood ES, Haslewood GA. The specificity of a 7 alpha-hydroxy steroid dehydrogenase from Escherichia coli. Biochem J. 1976 Jul 1;157(1):207-10. PMID:786279
  3. ↑ Hershkovitz L, Beuschlein F, Klammer S, Krup M, Weinstein Y. Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. Endocrinology. 2007 Mar;148(3):976-88. Epub 2006 Nov 22. PMID:17122075 doi:http://dx.doi.org/10.1210/en.2006-1100
  4. ↑ Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev. 2004 Oct;25(5):831-66. PMID:15466942 doi:http://dx.doi.org/10.1210/er.2003-0031
  5. ↑ Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Belanger A. The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology. Steroids. 1997 Jan;62(1):148-58. PMID:9029730
  6. ↑ de Launoit Y, Simard J, Durocher F, Labrie F. Androgenic 17 beta-hydroxysteroid dehydrogenase activity of expressed rat type I 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase. Endocrinology. 1992 Jan;130(1):553-5. PMID:1309351 doi:http://dx.doi.org/10.1210/endo.130.1.1309351
  7. ↑ Boehmer AL, Brinkmann AO, Sandkuijl LA, Halley DJ, Niermeijer MF, Andersson S, de Jong FH, Kayserili H, de Vroede MA, Otten BJ, Rouwe CW, Mendonca BB, Rodrigues C, Bode HH, de Ruiter PE, Delemarre-van de Waal HA, Drop SL. 17Beta-hydroxysteroid dehydrogenase-3 deficiency: diagnosis, phenotypic variability, population genetics, and worldwide distribution of ancient and de novo mutations. J Clin Endocrinol Metab. 1999 Dec;84(12):4713-21. PMID:10599740 doi:http://dx.doi.org/10.1210/jcem.84.12.6174
  8. ↑ Moisan AM, Ricketts ML, Tardy V, Desrochers M, Mebarki F, Chaussain JL, Cabrol S, Raux-Demay MC, Forest MG, Sippell WG, Peter M, Morel Y, Simard J. New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes. J Clin Endocrinol Metab. 1999 Dec;84(12):4410-25. PMID:10599696
  9. ↑ Stewart PM, Burra P, Shackleton CH, Sheppard MC, Elias E. 11 beta-Hydroxysteroid dehydrogenase deficiency and glucocorticoid status in patients with alcoholic and non-alcoholic chronic liver disease. J Clin Endocrinol Metab. 1993 Mar;76(3):748-51. PMID:8445034 doi:http://dx.doi.org/10.1210/jcem.76.3.8445034
  10. ↑ Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M. Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry. 1996 Aug 20;35(33):10702-11. PMID:8718859 doi:10.1021/bi9604688

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Michal Harel, Alexander Berchansky

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