6itb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Icosahedral asymmetric unit (iASU) model of the well-refined part of FHV eluted particle== | |
| - | + | <StructureSection load='6itb' size='340' side='right'caption='[[6itb]], [[Resolution|resolution]] 4.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6itb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ITB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nodavirus_endopeptidase Nodavirus endopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.44 3.4.23.44] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6itb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6itb OCA], [http://pdbe.org/6itb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6itb RCSB], [http://www.ebi.ac.uk/pdbsum/6itb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6itb ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV]] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Nodavirus endopeptidase]] | ||
| + | [[Category: Azad, K]] | ||
| + | [[Category: Banerjee, M]] | ||
| + | [[Category: Asymmetric reconstruction]] | ||
| + | [[Category: Disassembly intermediate]] | ||
| + | [[Category: Flock house virus]] | ||
| + | [[Category: Virus]] | ||
Revision as of 15:27, 28 August 2019
Icosahedral asymmetric unit (iASU) model of the well-refined part of FHV eluted particle
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