6qti
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of ovine transhydrogenase in the presence of NADP+ in a "double face-down" conformation== | |
| - | + | <StructureSection load='6qti' size='340' side='right'caption='[[6qti]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qti]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QTI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6que|6que]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qti OCA], [http://pdbe.org/6qti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qti RCSB], [http://www.ebi.ac.uk/pdbsum/6qti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qti ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NNTM_SHEEP NNTM_SHEEP]] The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity).[UniProtKB:P07001][UniProtKB:Q13423] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ovis aries]] | ||
| + | [[Category: Kampjut, D]] | ||
| + | [[Category: Sazanov, L A]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Mitochondrial]] | ||
| + | [[Category: Nicotinamide nucleotide transhydrogenase]] | ||
| + | [[Category: Proton-translocating]] | ||
Revision as of 15:35, 28 August 2019
Structure of ovine transhydrogenase in the presence of NADP+ in a "double face-down" conformation
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