6r4r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril== | |
| - | + | <StructureSection load='6r4r' size='340' side='right'caption='[[6r4r]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r4r]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R4R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r4r OCA], [http://pdbe.org/6r4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r4r RCSB], [http://www.ebi.ac.uk/pdbsum/6r4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r4r ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN]] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Buell, A K]] | ||
| + | [[Category: Gremer, L]] | ||
| + | [[Category: Hoyer, W]] | ||
| + | [[Category: Mangels, L N]] | ||
| + | [[Category: Ravelli, R B.G]] | ||
| + | [[Category: Roeder, C]] | ||
| + | [[Category: Schroder, G F]] | ||
| + | [[Category: Vettore, N]] | ||
| + | [[Category: Willbold, D]] | ||
| + | [[Category: Amyloid fibril]] | ||
| + | [[Category: Protein fibril]] | ||
| + | [[Category: Sh3 domain]] | ||
Revision as of 15:38, 28 August 2019
Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril
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