4crs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS== | ==Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS== | ||
| - | <StructureSection load='4crs' size='340' side='right' caption='[[4crs]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='4crs' size='340' side='right'caption='[[4crs]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4crs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRS FirstGlance]. <br> | <table><tr><td colspan='2'>[[4crs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRS FirstGlance]. <br> | ||
| Line 11: | Line 11: | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PKN2_HUMAN PKN2_HUMAN]] PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.<ref>PMID:9121475</ref> <ref>PMID:10226025</ref> <ref>PMID:10926925</ref> <ref>PMID:11781095</ref> <ref>PMID:11777936</ref> <ref>PMID:15364941</ref> <ref>PMID:17332740</ref> <ref>PMID:20188095</ref> <ref>PMID:20974804</ref> <ref>PMID:21754995</ref> | [[http://www.uniprot.org/uniprot/PKN2_HUMAN PKN2_HUMAN]] PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.<ref>PMID:9121475</ref> <ref>PMID:10226025</ref> <ref>PMID:10926925</ref> <ref>PMID:11781095</ref> <ref>PMID:11777936</ref> <ref>PMID:15364941</ref> <ref>PMID:17332740</ref> <ref>PMID:20188095</ref> <ref>PMID:20974804</ref> <ref>PMID:21754995</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 16: | Line 19: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Protein kinase C]] | [[Category: Protein kinase C]] | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
Revision as of 16:28, 28 August 2019
Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS
| |||||||||||
Categories: Human | Large Structures | Protein kinase C | Arrowsmith, C | Bountra, C | Cocking, R | Cooper, C D | Delft, F von | Edwards, A M | Elkins, J M | Knapp, S | Mathea, S | Newman, J A | Salah, E | Shrestha, B | Shrestha, L | Szklarz, M | Tallant, C | Tumber, A | Agc | Pkn2 | Prkcl2 | Transferase
