Insulin receptor

From Proteopedia

Revision as of 09:51, 29 August 2019

3D structures of insulin receptor

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• Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;

• • 1irk – hIR TK domain – human
    
  • 1i44, 1p14 – hIR TK domain (mutant)
    
  • 2hr7 – hIR domains 1-3
    
  • 4xst – hIR  L1-CR domains
    
  • 2mfr – hIR transmembrane domain - NMR
    

• Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;

• • 5j3h – hIR  L1-CR domains + antibody + peptide
    
  • 4xss – hIR  L1-CR domains + insulin-like growth factor 1
    
  • 4xlv - hIR TK domain (mutant) + ATP derivative
    
  • 1ir3 - hIR TK domain (mutant) + ATP analog + peptide
    
  • 3bu5, 3bu6 - hIR TK domain + ATP + peptide
    
  • 3bu3 - hIR TK domain + peptide
    
  • 1gag, 2z8c - hIR TK domain (mutant) + peptide
    
  • 3ekk, 3ekn, 4ibm, 5hhw - hIR TK domain (mutant) + inhibitor
    
  • 3eta, 5e1s - hIR TK domain + inhibitor
    
  • 4zxb - hIR ectodomain (mutant) + antibody
    
  • 2auh – hIR TK domain + growth factor receptor-bound protein 14
    
  • 2b4s - hIR TK domain + tyrosine-protein phosphatase
    
  • 1rqq – hIR TK domain (mutant) + adaptor protein PS
    
  • 6ce7, 6ce9, 6ceb – hIR + insulin ^[5]
    
  • 6hn4, 6hn5 - hIR + insulin ^[6]
    
  • 5kqv – hIR + insulin + antibody
    

References

1. ↑ Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34. PMID:8141246
2. ↑ Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem. 2008 Feb;114(1):23-37. doi: 10.1080/13813450801969715 . PMID:18465356 doi:http://dx.doi.org/10.1080/13813450801969715
3. ↑ Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar;15(3):251-8. Epub 2008 Feb 17. PMID:18278056 doi:10.1038/nsmb.1388
4. ↑ Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct, 17. PMID:27760050 doi:http://dx.doi.org/10.1172/JCI86013
5. ↑ Scapin G, Dandey VP, Zhang Z, Prosise W, Hruza A, Kelly T, Mayhood T, Strickland C, Potter CS, Carragher B. Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis. Nature. 2018 Feb 28. pii: nature26153. doi: 10.1038/nature26153. PMID:29512653 doi:http://dx.doi.org/10.1038/nature26153
6. ↑ Weis F, Menting JG, Margetts MB, Chan SJ, Xu Y, Tennagels N, Wohlfart P, Langer T, Muller CW, Dreyer MK, Lawrence MC. The signalling conformation of the insulin receptor ectodomain. Nat Commun. 2018 Oct 24;9(1):4420. doi: 10.1038/s41467-018-06826-6. PMID:30356040 doi:http://dx.doi.org/10.1038/s41467-018-06826-6