Insulin receptor

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</StructureSection>
</StructureSection>
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==3D structures of insulin receptor==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;
 
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**[[1irk]] – hIR TK domain – human<br />
 
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**[[1i44]], [[1p14]] – hIR TK domain (mutant) <br />
 
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**[[2hr7]] – hIR domains 1-3<br />
 
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**[[4xst]] – hIR  L1-CR domains <br />
 
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**[[2mfr]] – hIR transmembrane domain - NMR<br />
 
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*Insulin receptor; domains: L1-CR 28-337; 1-3 28-512; transmembrane 940-988; TK 1005-1310;
 
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**[[5j3h]] – hIR  L1-CR domains + antibody + peptide<br />
 
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**[[4xss]] – hIR  L1-CR domains + insulin-like growth factor 1<br />
 
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**[[4xlv]] - hIR TK domain (mutant) + ATP derivative<br />
 
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**[[1ir3]] - hIR TK domain (mutant) + ATP analog + peptide<br />
 
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**[[3bu5]], [[3bu6]] - hIR TK domain + ATP + peptide<br />
 
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**[[3bu3]] - hIR TK domain + peptide<br />
 
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**[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br />
 
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**[[3ekk]], [[3ekn]], [[4ibm]], [[5hhw]] - hIR TK domain (mutant) + inhibitor<br />
 
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**[[3eta]], [[5e1s]] - hIR TK domain + inhibitor<br />
 
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**[[4zxb]] - hIR ectodomain (mutant) + antibody<br />
 
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**[[2auh]] – hIR TK domain + growth factor receptor-bound protein 14<br />
 
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**[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br />
 
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**[[1rqq]] – hIR TK domain (mutant) + adaptor protein PS<br />
 
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**[[6ce7]], [[6ce9]], [[6ceb]] – hIR + insulin <ref>PMID:29512653</ref> <br />
 
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**[[6hn4]], [[6hn5]] - hIR + insulin <ref>PMID:30356040</ref><br />
 
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**[[5kqv]] – hIR + insulin + antibody<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:54, 29 August 2019

Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (cyan), Mg+2 ion (green) and ATP (PDB entry 3bu5)

Drag the structure with the mouse to rotate

References

  1. ↑ Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34. PMID:8141246
  2. ↑ Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem. 2008 Feb;114(1):23-37. doi: 10.1080/13813450801969715 . PMID:18465356 doi:http://dx.doi.org/10.1080/13813450801969715
  3. ↑ Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar;15(3):251-8. Epub 2008 Feb 17. PMID:18278056 doi:10.1038/nsmb.1388
  4. ↑ Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct, 17. PMID:27760050 doi:http://dx.doi.org/10.1172/JCI86013
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