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Interleukin receptor
From Proteopedia
(Difference between revisions)
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<StructureSection load='2b5i' size='340' side='right' caption='Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]]' scene=''> | <StructureSection load='2b5i' size='340' side='right' caption='Glycosylated interleukin-2 receptor α (yellow), β (green), γ (pink) chains complex with interleukin-2 (grey), [[2b5i]]' scene=''> | ||
'''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | '''Interleukin receptors''' (ILR) are cytokine receptor which are classified into type I, type II and others. '''ILR type I''' are cell surface receptors which recognize cytokines with four α-helical strands. '''ILR type II''' are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A). | ||
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| + | ==3D structures of interleukin receptor== | ||
| + | [[Interleukin receptor 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[5m5e]] - hIL2R β subunit + IL2 + cytokine receptor common subunit γ<br /> | **[[5m5e]] - hIL2R β subunit + IL2 + cytokine receptor common subunit γ<br /> | ||
**[[2b5i]] - hIL2R α+β+γ subunits + IL2<br /> | **[[2b5i]] - hIL2R α+β+γ subunits + IL2<br /> | ||
| - | **[[3qaz]] - hIL2R β+γ subunits + IL2<br /> | + | **[[3qaz]], [[6dg5]] - hIL2R β+γ subunits + IL2<br /> |
**[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)<br /> | **[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)<br /> | ||
**[[3qb7]] - hIL2R γ (mutant) subunit + IL2<br /> | **[[3qb7]] - hIL2R γ (mutant) subunit + IL2<br /> | ||
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**[[3bpl]] - hIL4R α + γ subunits + IL4<br /> | **[[3bpl]] - hIL4R α + γ subunits + IL4<br /> | ||
**[[3bpn]] - hIL4R α subunit + hIL13R α subunit + IL4<br /> | **[[3bpn]] - hIL4R α subunit + hIL13R α subunit + IL4<br /> | ||
| - | **[[3bpo]] - hIL4R α subunit + hIL13R α subunit + IL13 | + | **[[3bpo]] - hIL4R α subunit + hIL13R α subunit + IL13<br /> |
| + | **[[6oel]] - hIL4R α subunit + hIL2R γ subunit + IL4 + antibody<br /> | ||
*Interleukin-5 receptor | *Interleukin-5 receptor | ||
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**[[3qt2]] – hIL5R α (mutant) subunit + IL5<br /> | **[[3qt2]] – hIL5R α (mutant) subunit + IL5<br /> | ||
**[[3va2]] - hIL5R α subunit + IL5<br /> | **[[3va2]] - hIL5R α subunit + IL5<br /> | ||
| + | **[[6h41]] - hIL5R α subunit + peptide ihibitor<br /> | ||
*Interleukin-6 receptor or gp130 | *Interleukin-6 receptor or gp130 | ||
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**[[3g9v]] - hIL22R α subunit + IL22<br /> | **[[3g9v]] - hIL22R α subunit + IL22<br /> | ||
**[[3dgc]] – hIL22R α (mutant) subunit + IL22<br /> | **[[3dgc]] – hIL22R α (mutant) subunit + IL22<br /> | ||
| - | **[[3dlq]] - hIL22R α (mutant) subunit + IL2 (mutant) | + | **[[3dlq]] - hIL22R α (mutant) subunit + IL2 (mutant)<br /> |
| + | **[[6df3]] - hIL22R α subunit + hIL20R β subunit + IL24<br /> | ||
*Interleukin-28 receptor | *Interleukin-28 receptor | ||
Revision as of 09:33, 3 September 2019
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3D structures of interleukin receptor
Updated on 03-September-2019
