Kallikrein
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
KLK being a serine protease contains the <scene name='59/595822/Cv/5'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres. | KLK being a serine protease contains the <scene name='59/595822/Cv/5'>Ser, His, Asp catalytic triad and the Gly, Ser oxyanion hole</scene><ref>PMID:16950394</ref>. Water molecules shown as red spheres. | ||
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| + | == 3D Structures of kallikrein == | ||
| + | [[Kallikrein 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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*Kallikrein 4 | *Kallikrein 4 | ||
| + | **[[6nvb]] – hKLK <br /> | ||
**[[4kga]] – hKLK + Ni<br /> | **[[4kga]] – hKLK + Ni<br /> | ||
**[[2bdg]] – hKLK + aminobenzamidine + Ni <br /> | **[[2bdg]] – hKLK + aminobenzamidine + Ni <br /> | ||
**[[2bdh]] – hKLK + aminobenzamidine + Zn<br /> | **[[2bdh]] – hKLK + aminobenzamidine + Zn<br /> | ||
**[[2bdi]] – hKLK + aminobenzamidine + Co<br /> | **[[2bdi]] – hKLK + aminobenzamidine + Co<br /> | ||
| - | **[[4k1e]], [[4kel]], [[4k8y]] – hKLK + trypsin inhibitor <br /> | + | **[[4k1e]], [[4kel]], [[4k8y]], [[6o21]] – hKLK + trypsin inhibitor <br /> |
| + | **[[6kbr]] – hKLK + SPINK2 inhibitor <br /> | ||
*Kallikrein 5 | *Kallikrein 5 | ||
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**[[2psx]] – hKLK catalytic domain + leupeptin<br /> | **[[2psx]] – hKLK catalytic domain + leupeptin<br /> | ||
**[[2psy]] – hKLK catalytic domain + leupeptin + Zn<br /> | **[[2psy]] – hKLK catalytic domain + leupeptin + Zn<br /> | ||
| + | **[[6qfe]] – hKLK + inhibitor <br /> | ||
*Kallikrein 6 | *Kallikrein 6 | ||
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**[[1gvl]] – hKLK (mutant) <br /> | **[[1gvl]] – hKLK (mutant) <br /> | ||
**[[1l2e]], [[1lo6]] – hKLK + inhibitor <br /> | **[[1l2e]], [[1lo6]] – hKLK + inhibitor <br /> | ||
| - | **[[3vfe]], [[4d8n]] – hKLK (mutant) + inhibitor <br /> | + | **[[3vfe]], [[4d8n]], [[6qff]], [[6qfg]], [[6qfh]], [[6qf9]], [[6qfa]], [[6qfb]], [[6qfc]] – hKLK (mutant) + inhibitor <br /> |
**[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br /> | **[[5nx1]], [[5nx3]] – hKLK + amyloid-b A4 protein<br /> | ||
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**[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br /> | **[[5fah]], [[5y9l]], [[5yjk]] – hKLK + inhibitor<br /> | ||
**[[5zfh]] – mKLK - mouse<br /> | **[[5zfh]] – mKLK - mouse<br /> | ||
| - | **[[5zfi]] – mKLK + inhibitor<br /> | + | **[[5zfi]], [[6ahs]] – mKLK + inhibitor<br /> |
*Kallikrein 8 | *Kallikrein 8 | ||
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*Plasma kallikrein | *Plasma kallikrein | ||
| + | **[[6o1g]], [[6i44]] – hKLK + inhibitor<br /> | ||
**[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br /> | **[[4ogx]], [[4ogy]] – hKLK light chain (mutant) + antibody <br /> | ||
**[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br /> | **[[5f8z]] – hKLK light chain (mutant) + Pkalin-1 <br /> | ||
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**[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br /> | **[[5f8x]] – hKLK light chain (mutant) + Pkalin-3 <br /> | ||
**[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br /> | **[[5tjx]], [[2anw]], [[2any]], [[6o1s]] – hKLK light chain (mutant) + inhibitor <br /> | ||
| - | **[[5gvt]] – mKLK | + | **[[5gvt]] – mKLK protease domain (mutant) <br /> |
| + | **[[6a8o]] – mKLK protease domain + inhibitor<br /> | ||
*Tissue kallikrein (KLK 1) | *Tissue kallikrein (KLK 1) | ||
Revision as of 09:11, 8 September 2019
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3D Structures of kallikrein
Updated on 08-September-2019
References
- ↑ Bryant JW, Shariat-Madar Z. Human plasma kallikrein-kinin system: physiological and biochemical parameters. Cardiovasc Hematol Agents Med Chem. 2009 Jul;7(3):234-50. PMID:19689262
- ↑ Feener EP. Plasma kallikrein and diabetic macular edema. Curr Diab Rep. 2010 Aug;10(4):270-5. doi: 10.1007/s11892-010-0127-1. PMID:20535647 doi:http://dx.doi.org/10.1007/s11892-010-0127-1
- ↑ Pampalakis G, Sotiropoulou G. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer. Biol Chem. 2006 Jun;387(6):773-82. PMID:16800739 doi:http://dx.doi.org/10.1515/BC.2006.097
- ↑ Cerqueira C, Samperio Ventayol P, Vogeley C, Schelhaas M. Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells. J Virol. 2015 Jul;89(14):7038-52. doi: 10.1128/JVI.00234-15. Epub 2015 Apr 29. PMID:25926655 doi:http://dx.doi.org/10.1128/JVI.00234-15
- ↑ Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, Friedrich R, Bode W, Goettig P. Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site. J Mol Biol. 2006 Oct 6;362(5):1094-107. Epub 2006 Aug 3. PMID:16950394 doi:10.1016/j.jmb.2006.08.003
